Results 131 to 140 of about 802,187 (333)
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Scientific ReportsInternal solitary waves (ISWs) are extreme oceanic dynamic processes that significantly modulate sea surface currents and roughness, but their roles in air-sea interactions are still poorly understood.
Zeyu Chang +6 more
doaj +1 more source
A global low order spectral model designed for climate sensitivity studies [PDF]
, 1984 A two level, global, spectral model using pressure as a vertical coordinate is developed. The system of equations describing the model is nonlinear and quasi-geostrophic.
Hanna, A. F., Stevens, D. E.
core +1 more source
The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source
Surface temperatures and temperature gradient features of the US Gulf Coast waters [PDF]
Satellite thermal infrared data on the Gulf of Mexico show that a seasonal cycle exists in the horizontal surface temperature structure. In the fall, the surface temperatures of both coastal and deep waters are nearly uniform.
Huh, O. K. +2 more
core +1 more source
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
Sea Surface Temperatures Drive Historical Demography of Deep-Sea Fishes [PDF]
, 2021 Max Weber +2 more
openalex +1 more source
On the relationship between water vapor over the oceans and sea surface temperature [PDF]
Monthly mean precipitable water data obtained from passive microwave radiometry were correlated with the National Meteorological Center (NMC) blended sea surface temperature data.
Stephens, Graeme L.
core +1 more source
Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source
Solar cycle signals in sea level pressure and sea surface temperature [PDF]
Atmospheric Chemistry and Physics, 2010 We identify solar cycle signals in 155 years of global sea level pressure (SLP) and sea surface temperature (SST) data using a multiple linear regression approach.
I. Roy, J. D. Haigh
doaj