Results 51 to 60 of about 28,654 (264)

Spatial Variability of Sea State in the German Bight and Influence of Offshore Wind Farms

Wind Energy
Offshore wind farms are growing worldwide and increase the source of renewable energy. However, as the extent and density of offshore wind farms increase, there is growing importance to understand the interactions with physical systems and the marine ...
Lea Schmitt, Konrad B. Bärfuss, Xiaoli Guo Larsén, Jana Fischereit, Astrid Lampert   +4 more
doaj   +1 more source

On the Dependence of Sea Surface Roughness on Wind Waves

Journal of Physical Oceanography, 1998
Abstract The influence of wind waves on the momentum transfer (wind stress) between the atmosphere and sea surface was studied using new measured data from the RASEX experiment and other datasets compiled by Donelan et al. Results of the data analysis indicate that errors in wind friction velocity u∗ of about ±10% make it difficult to conclude on the ...
H. K. Johnson, J. Højstrup, H. J. Vested, S. E. Larsen   +3 more
openaire   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Sea wave modeling with X-band COSMO-SkyMed^© SAR-derived wind field forcing and applications in coastal vulnerability assessment [PDF]

Ocean Science, 2013
In this paper, X-band COSMO-SkyMed© synthetic aperture radar (SAR) wind field data are first used to force coastal wind wave modeling for both sea wave numerical simulation and coastal vulnerability assessment purposes. The SAR-based wind field retrieval
G. Benassai, A. Montuori, M. Migliaccio, F. Nunziata   +3 more
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Roughness Analysis of Sea Surface From Visible Images by Texture

IEEE Access, 2020
This paper presents a roughness analysis of sea surface from visible images by feature measurements of texture for the first time. The algorithms presented in this paper include six texture feature measurements of sea surface use gray level co-occurrence
Hailang Pan, Peilin Gao, Huicheng Zhou, Ruixue Ma, Jingsong Yang, Xin Zhang   +5 more
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Ocean Surface Anomalies after Strong Winds in the Western Mediterranean Sea

Journal of Marine Science and Engineering, 2019
The Western Mediterranean Sea is often subject to intense winds, especially during the winter season. Intense winds induce surface cooling associated with anomalous ocean heat loss, upwelling and diapycnal mixing. In this study we investigate the overall
Francesco Ragone, Andrea Meli, Anna Napoli, Claudia Pasquero   +3 more
doaj   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source