Results 61 to 70 of about 28,654 (264)
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Surveying sea surface effect in satellite altimeter-derived wind speed
International Journal of Coastal and Offshore Engineering, 2016 To improve sea surface wind speed in coastal regions, we used nadir satellite altimeter measurements in the Persian Gulf and Arabian Sea. With combining normalized radar cross section for two bands of satellite altimeter measurements and significant wave
Hossein Farjami +2 more
doaj
Sea surface circulation in the Baltic Sea: decomposed components and pattern recognition
Scientific ReportsBy decomposing the total sea surface current into its geostrophic and ageostrophic components, we examined the contribution of each to the long-term variability of the total sea surface current.
Amirhossein Barzandeh +6 more
doaj +1 more source
Известия ТИНРО, 2017 Data of observations on drifting buoys in the western Okhotsk Sea are presented. Quasi-stochastic mode of the buoys drift under forcing of atmospheric cyclone is noted.
Igor I. Usoltsev +2 more
doaj +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Assessment of Sea-Surface Wind Retrieval from C-Band Miniaturized SAR Imagery. [PDF]
Sensors (Basel), 2023 Wang Y +6 more
europepmc +1 more source
Probability distribution of sea surface wind stresses [PDF]
Geophysical Research Letters, 2008 The probability density function (pdf) of sea surface wind stresses is considered. Observed sea surface wind stresses are highly non‐Gaussian, with characteristic relationships between moments. A consideration of empirical models of sea surface wind stress pdfs built from models of sea surface vector winds demonstrates that non‐Gaussian structure in ...
openaire +1 more source