Results 71 to 80 of about 29,732 (262)
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani +9 more
wiley +1 more source
A Real-Time GNSS-R System for Monitoring Sea Surface Wind Speed and Significant Wave Height. [PDF]
Xing J +6 more
europepmc +1 more source
On the Dependence of Sea Surface Roughness on Wind Waves
Abstract The influence of wind waves on the momentum transfer (wind stress) between the atmosphere and sea surface was studied using new measured data from the RASEX experiment and other datasets compiled by Donelan et al. Results of the data analysis indicate that errors in wind friction velocity u∗ of about ±10% make it difficult to conclude on the ...
H. K. Johnson +3 more
openaire +1 more source
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez +5 more
wiley +1 more source
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault +12 more
wiley +1 more source
INTERANNUAL VARIABILITY OF THE KUROSHIO CURRENT INTRUSION IN THE SOUTH CHINA SEA
The interannual variability of the Kuroshio Current intrusion into the South China Sea is investigated using a combination of satellite remote sensing data and in situ measurements.
Michael J Caruso +2 more
doaj
The impact of sea breezes on offshore wind energy resources in Australia [PDF]
Future projected increases in offshore wind energy in Australia means that it is important to understand variability in wind resources. This includes the potential diurnal variation of wind, along with its co-variability with known diurnal variations of ...
A. Brown +3 more
doaj +1 more source
Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim +11 more
wiley +1 more source
Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba +5 more
wiley +1 more source
Sea Surface Roughness Observed by High Resolution Radar
Changes in the sea surface roughness are usually associated with a change in the sea surface wind field [...]
Atsushi Fujimura +3 more
doaj +1 more source

