Results 81 to 90 of about 439,158 (345)

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

Variation of air--water gas transfer with wind stress and surface viscoelasticity [PDF]

, 1995
Previous parameterizations of gas transfer velocity have attempted to cast this quantity as a function of wind speed or wind-stress. This study demonstrates that the presence of a surface film is effective at reducing the gas transfer velocity at ...
Frew, Nelson M., Jähne, Bernd, Karachintsev, Andrey V., Bock, Erik J., Münsterer, Thomas, Hara, Tetsu, McGillis, Wade R.   +6 more
core   +1 more source

Kuroshio Extension cold-core ring and wind drop-off observed in 2021–2022 winter

Progress in Earth and Planetary Science
Energetic cyclonic mesoscale eddies, which are called cold-core rings and are shed southward from the Kuroshio Extension jet and form closed streamlines, affect the atmosphere through the heat exchange across the sea surface. To investigate the effect of
Akira Nagano, Minoru Kitamura, Kensuke Watari, Iwao Ueki   +3 more
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

On the Dependence of Sea Surface Roughness on Wind Waves

Journal of Physical Oceanography, 1998
Abstract The influence of wind waves on the momentum transfer (wind stress) between the atmosphere and sea surface was studied using new measured data from the RASEX experiment and other datasets compiled by Donelan et al. Results of the data analysis indicate that errors in wind friction velocity u∗ of about ±10% make it difficult to conclude on the ...
H. K. Johnson, J. Højstrup, H. J. Vested, S. E. Larsen   +3 more
openaire   +1 more source

Spatial Variability of Sea State in the German Bight and Influence of Offshore Wind Farms

Wind Energy
Offshore wind farms are growing worldwide and increase the source of renewable energy. However, as the extent and density of offshore wind farms increase, there is growing importance to understand the interactions with physical systems and the marine ...
Lea Schmitt, Konrad B. Bärfuss, Xiaoli Guo Larsén, Jana Fischereit, Astrid Lampert   +4 more
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Surface forcing of the North Atlantic: accuracy and variability [PDF]

, 2009
A new methodology to estimate the turbulent air – sea heat and moisture fluxes andtheir uncertainty is developed and assessed using Voluntary Observing Ship (VOS)observations.
Berry, David Inglis
core  

Sea wave modeling with X-band COSMO-SkyMed^© SAR-derived wind field forcing and applications in coastal vulnerability assessment [PDF]

Ocean Science, 2013
In this paper, X-band COSMO-SkyMed© synthetic aperture radar (SAR) wind field data are first used to force coastal wind wave modeling for both sea wave numerical simulation and coastal vulnerability assessment purposes. The SAR-based wind field retrieval
G. Benassai, A. Montuori, M. Migliaccio, F. Nunziata   +3 more
doaj   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source