Results 101 to 110 of about 202,076 (312)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Core-top calibration of δ18O and δ13C of G. ruber (white) and U. mediterranea along the southern Adriatic coast of Italy

We carried out an extensive survey of the oxygen and carbon isotope composition of the planktic species G. ruber (white) and of the benthic species U.
Bernasconi, S.M., Grauel, A. L.
core   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Effects of water temperature and pH value on covering behavior of the sea urchin Glyptocidaris crenularis

Invertebrate Survival Journal, 2017
As marine calcifying organisms, sea urchins are sensitive in the changing ocean. More information is needed about the effects of pH value and water temperature on behaviors of sea urchins.
M F Yang, S B Luo, J N Sun, D T Shi, J Y Ding, Y Q Chang, C Zhao   +6 more
doaj  

Variability in Water Temperature Vertical Distribution and Advective Influences: Observations from Early Summer 2021 in the Central Yellow Sea

Journal of Marine Science and Engineering
To analyze variations in the vertical distribution of water temperatures and the impact of advection in the central Yellow Sea, multi-layer water temperature and current observations were conducted from 31 May to 8 June 2021. Water temperatures exhibited
Baekjin Kim, Seonghyeon Kim, Soonyeol Kwon, Donhyug Kang, Eung Kim   +4 more
doaj   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Sea surface temperature trends in the coastal ocean

, 2013
Sea surface temperature (SST) trends in the coastal zone are shown to be increasing at rates that exceed the global trends by up to an order of magnitude. This paper compiles some of the evidence of the trends published in the literature.
Al-Rashidi, Thamer B., Nicholls, R.J., Rakha, Karim, Amos, C.L., El-Gamily, Hamdy   +4 more
core  

Interannual variability of the Barents Sea branch water in the northeastern part of the Barents Sea and the St. Anna Trough

Frontiers in Marine Science
In this work, we describe the inter-annual variability of the Barents Sea branch water (BSBW), which is one of the main branches of the Atlantic water that flows from the North Atlantic to the Western Arctic.
Zinaida Zabudkina, Zinaida Zabudkina, Alexander Osadchiev, Alexander Osadchiev, Alexander Osadchiev, Vladimir Ivanov, Vladimir Ivanov, Mikhail Makhotin, Viktor Merkulov   +8 more
doaj   +1 more source

The Effect of the Sea and Land Water on the Soil Temperature

Annals of The Tohoku Geographycal Asocciation, 1965
The author investigated the relation between the distance from the shore or bank to the station (D) and the thermal conductivity which is here represented by the amplitude ratio of soil temperatures (A3/A1). (AX means the annual amplitude of soil temperature at x m depth.
openaire   +2 more sources

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source