Results 111 to 120 of about 202,076 (312)
Calving rates at tidewater glaciers vary strongly with ocean temperature [PDF]
, 2015 TerraSAR-X data were provided by DLR (project OCE1503), and funded by the Conoco Phillips-Lundin Northern Area Program through the CRIOS project (Calving Rates and Impact on Sea level). A.L. and S.B.
Luckman, Adrian +14 more
core +1 more source
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
Methane fluxes at the water–atmosphere boundary in the waters of the Russian sector of the Eastern Arctic [PDF]
Геосистемы переходных зонThe average value of methane fluxes from the sea surface in the Chukchi Sea (4±4 mol/(km2‧day)) and parameters of methane supersaturation of the surface water layer (78±39 %) were lower than in the East Siberian Sea (32±24 mol/(km2‧day) and 346±247 ...
Galina I. Mishukova
doaj +1 more source
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Formation of Barents Sea Branch Water in the north-eastern Barents Sea
Polar Research, 2013 The Barents Sea throughflow accounts for approximately half of the Atlantic Water advection to the Arctic Ocean, while the other half flows through Fram Strait.
Vidar S. Lien, Alexander G. Trofimov
doaj +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Reproduction and larval biology of North Atlantic asteroids related to the invasion of the deep sea
, 2005 A very important objective of ecological research is to explain the evolution of life histories, more specifically how natural selection modifies reproduction and development in order to generate the patterns that are observed in nature.
Benitez Villalobos, F.
core
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source