Results 41 to 50 of about 32,394 (293)
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
Romanian Journal of Transport Infrastructure, 2020 The study provided economic justification for private sector investment in developing, revitalizing and making operable, the rail-freight-corridors between hub-seaports and inland container depots in Nigeria.
Nwokedi Theophilus Chinonyerem +3 more
doaj +1 more source
Seaport efficiency and the trade balance in Africa
Maritime Transport Research, 2021 Seaports and their efficiency are particularly important for international trade flows and the trade balance. Notwithstanding the efficiency of seaports, there exists no empirical evidence on how it influences the trade balance.
Daniel Sakyi, Mustapha Immurana
doaj +1 more source
FEBS Letters, EarlyView.This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source
Malaysian Container Seaport-Hinterland Connectivity: Status, Challenges and Strategies
Asian Journal of Shipping and Logistics, 2016 This paper adopts a qualitative methodology to assess the Malaysian container seaport-hinterland connectivity from the perspective of its physical properties.
Shu-Ling Chen +2 more
doaj +1 more source
Strategic correlations for maritime clusters [PDF]
, 2019 Maritime clusters formulate appealing objects of study, for many viewpoints. At the same time, the theory is not homogenous nor compartmentalized, although some main themes do seem to be prevalent. The latter include innovation, competitiveness, strategy,
Koliousis, Ioannis +4 more
core +1 more source
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
FEBS Letters, EarlyView.Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley +1 more source
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
Journal of Transportation and Logistics, 2022 Seaports are nodal points in global supply chains. Industry 4.0 applications, which have entered our lives with the rapid technological developments, are also seen in the port sector. The use of Industry 4.0 technologies started in container ports first,
Elif Koç
doaj +1 more source