Results 41 to 50 of about 7,043 (308)
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
System Dynamics Approach to Global Shipping Emissions [PDF]
TransNavThis paper presents an improved System Dynamics (SD) model to assess the greenhouse gas (GHG) emission reduction measures between 2023 and 2050 at the container terminal of the Port of Koper.
Marin Hero +2 more
doaj +1 more source
Enhancing the resilience of seaports to a changing climate: research synthesis and implications for policy and practice [PDF]
, 2013 This report synthesises the research findings from the ‘Climate Resilient Seaports’ project funded by NCCARF and conducted between 2011 and 2012. The intention of the project was to contribute to an emerging knowledge base relating to climate change and
Jane Mullett, Darryn McEvoy
core
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
, 2007 The different types of entry barrier in seaports are analysed and the policies and practices to reduce them are discussed in this paper. In most seaports, economic, regulatory, and geographical entry barriers are substantial and increasing in complexity ...
Langen, de, P.W. +4 more
core +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Malaysian Container Seaport-Hinterland Connectivity: Status, Challenges and Strategies
Asian Journal of Shipping and Logistics, 2016 This paper adopts a qualitative methodology to assess the Malaysian container seaport-hinterland connectivity from the perspective of its physical properties.
Shu-Ling Chen +2 more
doaj +1 more source
The Logistics Components of the Sea Ports of Ukraine: Renewal of the Organizationally-Legal Support [PDF]
Lex Portus, 2018 The article is devoted to the research of factors, which have a significant impact on the increase of competitiveness and achievement of efficiency of logistic systems, which is part of the sea ports of Ukraine.
Sergiy Andrushchenko
doaj +1 more source