Results 51 to 60 of about 32,394 (293)

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

World cities and global commodity chains: an introduction [PDF]

, 2010
The purpose of this special anniversary issue is to assess the possible cross-fertilization between two prominent analytical frameworks: the World City Network framework, in which researchers have studied the emergence of a globalized urban system for ...
Alderson, Bair, Beaverstock, Beaverstock, Brown, Castells, Castells, Choi, Clancy, Coe, Coe, Coe, Coe, Cohen, Derudder, Derudder, Derudder, Derudder, Derudder, Dicken, Faulconbridge, Friedmann, Gereffi, Hanssens, Hassler, Henderson, Hesse, Jacobs, Lüthi, Massey, Morgan, Neal, Palpacuer, Parnreiter, Rabach, Robinson, Robinson, Rossi, Rothenberg-Aalami, Rozenblat, Sassen, Sassen, Sassen, Sheppard, Taylor, Taylor, Taylor, Tokatli, Vind, Yeung   +49 more
core   +3 more sources

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

Ukrainian Maritime Industry under Fire: Consequences of Russian Invasion

Lex Portus, 2022
The maritime industry in Ukraine has now been under significant pressure for eight years. The illegal annexation of Crimea by the Russian Federation in 2014 created a gray area which included a portion of Ukrainian coastal waters around Crimea, where ...
Borys Kormych, Tetiana Averochkina
doaj   +1 more source

Information technologies as a way of port activity optimization in conditions of digital economy [PDF]

E3S Web of Conferences, 2019
The use of digital solutions in various fields of activity today allows you to adapt to the digital needs of customers. The adoption of information technology by the subjects of the transport complex was not quick at the beginning, but development has ...
Koroleva Elena, Sokolov Sergey, Makashina Irina, Filatova Evgeniya   +3 more
doaj   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Maritime Pilotage and Sustainable Seaport: A Systematic Review

Journal of Marine Science and Engineering
The long-term sustainability of seaports depends on various operational factors, including infrastructure efficiency, digital innovation, environmental management, and regulatory compliance, among which maritime pilotage plays a crucial role in ensuring ...
Seyed Behbood Issa-Zadeh, Claudia Lizette Garay-Rondero   +1 more
doaj   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source