Results 51 to 60 of about 32,565 (293)
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
FEBS Letters, EarlyView.This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source
Biallelic Inactivation of NSD1 Associated With Carcinogenesis in Sotos Syndrome
Pediatric Blood &Cancer, EarlyView.
Nicholas A. Borja +8 more
wiley +1 more source
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
Maritime Pilotage and Sustainable Seaport: A Systematic Review
Journal of Marine Science and EngineeringThe long-term sustainability of seaports depends on various operational factors, including infrastructure efficiency, digital innovation, environmental management, and regulatory compliance, among which maritime pilotage plays a crucial role in ensuring ...
Seyed Behbood Issa-Zadeh +1 more
doaj +1 more source
Ukrainian Maritime Industry under Fire: Consequences of Russian Invasion
Lex Portus, 2022 The maritime industry in Ukraine has now been under significant pressure for eight years. The illegal annexation of Crimea by the Russian Federation in 2014 created a gray area which included a portion of Ukrainian coastal waters around Crimea, where ...
Borys Kormych, Tetiana Averochkina
doaj +1 more source
Information technologies as a way of port activity optimization in conditions of digital economy [PDF]
E3S Web of Conferences, 2019 The use of digital solutions in various fields of activity today allows you to adapt to the digital needs of customers. The adoption of information technology by the subjects of the transport complex was not quick at the beginning, but development has ...
Koroleva Elena +3 more
doaj +1 more source
FEBS Letters, EarlyView.Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson +7 more
wiley +1 more source
Економіка та суспільствоIn the current context of global fragmentation, geopolitical instability, and intensifying strategic rivalry among leading states, seaports are acquiring a new functional significance – shifting from transport-logistics hubs to instruments of ...
Наталія Шлафман +2 more
doaj +1 more source