Results 31 to 40 of about 43,729 (268)
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Searching for Suicide Information on Web Search Engines in Chinese
Journal of Medical Sciences, 2017 Introduction: Recently, suicide prevention has been an important public health issue. However, with the growing access to information in cyberspace, the harmful information is easily accessible online.
Yen-Feng Lee +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
Children's search engines on the Internet: an analytical study
Cybrarians JournalThe study focused on children's search engines with the main objective of cataloging the available children's search engines on the Internet and evaluating their strengths and weaknesses. A survey and analytical method were employed to achieve this goal.
Mohamed Al-Farjani
doaj +1 more source
Iranian Journal of Information Processing & Management, 2022 The aim of this study was to investigate the image retrieval from selected search engines according to the written and semantic features of Persian language and determine their relevance using recall and precision formulas and to identify the most ...
Yaghub Norouzi +2 more
doaj
AIB Studi, 2018 Il contributo propone una riflessione sul concetto di neutralità sia in riferimento a Internet e ai motori di ricerca, sia alle biblioteche. Nella prima parte, attraverso la presentazione di esempi e il rimando ad alcuni studi sul tema, l’autrice sfata ...
Karen Coyle
doaj +1 more source
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
pp-Blast: a "pseudo-parallel" Blast
Brazilian Journal of Medical and Biological Research, 2003 We have developed a software called pp-Blast that uses the publicly available Blast package and PVM (parallel virtual machine) to partition a multi-sequence query across a set of nodes with replicated or shared databases.
E.C. Osório +4 more
doaj +1 more source
Interactive Search on the Web: The Story So Far
Information, 2022 Search on the web, specifically fetching of the relevant content, has been paid attention to since the advent of the web and particularly in recent years due to the tremendous growth in the volume of data and web pages.
Sareh Aghaei +5 more
doaj +1 more source
Molecular Oncology, EarlyView.Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau +8 more
wiley +1 more source