Results 61 to 70 of about 2,927,637 (247)
Qualitative ranking of Persian and non-Persian search engines in information retrieval of Islamic subjects [PDF]
کتابداری و اطلاعرسانی, 2016 Purpose: The purpose of this study was to determine the quality of the content of web pages in the Islamic domain retrieved by Persian and non Persian search engines. Methodology:This was an applied research carried out through descriptive survey. A self-
Naeimeh Morvarid +2 more
doaj
Edusaintek, 2023 The background of this research is to help Micro, Small and Medium Enterprises (MSMEs) which need promotional media in the form of websites. Therefore the author has an idea to implement SEO (Search Engine Optimization). SEO (Search Engine Optimization)
Isbandi Isbandi +2 more
doaj +1 more source
Prospecting the protein design landscape
FEBS Letters, EarlyView.This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona +4 more
wiley +1 more source
Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research
FEBS Letters, EarlyView.What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley +1 more source
Web Searching: A Quality Measurement Perspective [PDF]
, 2007 The purpose of this paper is to describe various quality measures for search engines and to ask whether these are suitable. We especially focus on user needs and their use of web search engines.
Lewandowski, Dirk +3 more
core +2 more sources
OPTIMIZING KEYWORD SEARCH FOR SEARCH ENGINES USING BLOCKCHAIN TECHNOLOGY [PDF]
Proceedings on Engineering SciencesThe traditional SEO landscape, reliant on algorithmic changes and privacy concerns, demands new solutions. This research explores the integration of blockchain technology into SEO to boost website visibility without compromising user privacy.
Bharti Aggarwal +2 more
doaj +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source