Results 81 to 90 of about 2,143,335 (271)
FEBS Letters, EarlyView.This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source
Adolescents’ academic achievement and meaning in life: the role of self-concept clarity
Frontiers in PsychologySense of meaning in life is closely related to adolescents’ well-being. While prior research has largely examined the effects of individual traits and environmental influences, adolescents’ personal experiences (e.g., academic achievement) also play a ...
Fang Liu +4 more
doaj +1 more source
Contextual Effects on Metaphor Comprehension: Experiment and Simulation [PDF]
, 2003 This paper presents a computational model of referential metaphor comprehension. This model is designed on top of Latent Semantic Analysis (LSA), a model of the representation of word and text meanings.
Bianco, Maryse, Lemaire, Benoit
core +1 more source
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
SCIENCE‐AND‐RELIGION AND THE SEARCH FOR MEANING
Zygon, 1996 . A survey and interpretation is offered of the broad range of contemporary thinking that concerns itself with the relationships between religion and science.
doaj +2 more sources
FEBS Letters, EarlyView.Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson +7 more
wiley +1 more source
UNDERSTANDING PREPOSITIONS THROUGH COGNITIVE GRAMMAR. A CASE OF IN [PDF]
, 2004 Poly - semantic nature of prepositions has been discussed in linguistic literature and confirmed by language data. In the majority of research within cognitive linguistics prepositions have been approached as predicates organising entities in space, with
Turewicz, prof. Kamila
core
β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1
Molecular Oncology, EarlyView.Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero +8 more
wiley +1 more source
Molecular Oncology, EarlyView.AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou +5 more
wiley +1 more source
What is the Astrophysical Meaning of the Intermediate Subgroup of GRBs?
, 2015 Published articles concerning the intermediate (third) subgroup of GRBs are surveyed. From a statistical perspective this subgroup may exist, however its significance depends on which data set is used.
Meszaros, A., Ripa, J.
core +1 more source