Results 61 to 70 of about 185,887 (355)

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

Successive Cancellation List Polar Decoder using Log-likelihood Ratios

, 2014
Successive cancellation list (SCL) decoding algorithm is a powerful method that can help polar codes achieve excellent error-correcting performance. However, the current SCL algorithm and decoders are based on likelihood or log-likelihood forms, which ...
Parhi, Keshab K., Yuan, Bo
core   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

The Search-o-Sort Theory

AppliedMath
In the modern era of informatics, where data are very important, efficient management of data is necessary and critical. Two of the most important data management techniques are searching and data ordering (technically sorting).
Anurag Dutta, Sanjeev Kumar, Deepkiran Munjal, Pijush Kanti Kumar   +3 more
doaj   +1 more source

Tumor and germline testing with next generation sequencing in epithelial ovarian cancer: a prospective paired comparison using an 18‐gene panel

Molecular Oncology, EarlyView.
Genetic testing in epithelial ovarian cancer includes both germline and tumor‐testing. This approach often duplicates resources. The current prospective study assessed the feasibility of tumor‐first multigene testing by comparing tumor tissue with germline testing of peripheral blood using an 18‐gene NGS panel in 106 patients.
Elisabeth Spenard, Cristina Mitric, Melanie Care, Tracy L. Stockley, Raymond H. Kim, Jeanna McCuaig, Blaise Clarke, Laura Ranich, Clare Sheen, Sarah E. Ferguson, Liat Hogen, Taymaa May, Marcus Q. Bernardini   +12 more
wiley   +1 more source

MicroRNAs and other small RNAs in Aedes aegypti saliva and salivary glands following chikungunya virus infection

Scientific Reports, 2022
Mosquito saliva facilitates blood feeding through the anti-haemostatic, anti-inflammatory and immunomodulatory properties of its proteins. However, the potential contribution of non-coding RNAs to host manipulation is still poorly understood. We analysed
Carmine Fiorillo, Pei-Shi Yen, Alessio Colantoni, Marina Mariconti, Nayara Azevedo, Fabrizio Lombardo, Anna-Bella Failloux, Bruno Arcà   +7 more
doaj   +1 more source

Self-Improving Algorithms

, 2010
We investigate ways in which an algorithm can improve its expected performance by fine-tuning itself automatically with respect to an unknown input distribution D. We assume here that D is of product type.
Ailon, Nir, Chazelle, Bernard, Clarkson, Kenneth L., Liu, Ding, Mulzer, Wolfgang, Seshadhri, C.   +5 more
core   +2 more sources

Glycosylated LGALS3BP is highly secreted by bladder cancer cells and represents a novel urinary disease biomarker

Molecular Oncology, EarlyView.
Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece, Giulio Lovato, Ilaria Cela, Arianna Mercatelli, Benedetta Ferro, Jussi Nikkola, Sara Pagotto, Tommaso Grottola, Vincenzo De Laurenzi, Rossella Cicchetti, Antonio Marchetti, Luigi Schips, Rossano Lattanzio, Stefano Iacobelli, Emily Capone, Peter Black, Mads Daugaard, Michele Marchioni, Gianluca Sala   +18 more
wiley   +1 more source

A New Hybrid Metaheuristic Algorithm for Multiobjective Optimization Problems

International Journal of Computational Intelligence Systems, 2020
The elitist nondominated sorting genetic algorithm (NSGA-II) is hybridized with the sine-cosine algorithm (SCA) in this paper to solve multiobjective optimization problems.
M.A. Farag, A.A. Mousa, M.A. El-Shorbagy, I.M. El-Desoky, A.A. Mousa, I.M. El-Desoky   +5 more
doaj   +1 more source

Standard versus uniform binary search and their variants in learned static indexing: The case of the searching on sorted data benchmarking software platform [PDF]

, 2022
Domenico Amato, Giosuè Lo Bosco, Raffaele Giancarlo   +2 more
openalex   +1 more source