Results 111 to 120 of about 7,941 (202)

Assessing the effect of seasonal malaria chemoprevention on malaria burden among children under 5 years in Burkina Faso

Malaria Journal, 2022
Background In 2014, the Burkina Faso government launched the Seasonal Malaria Chemoprevention (SMC) programme. Expected benefit was a 75% reduction of all malaria episodes and a 75% drop of severe malaria episodes.
Fati Kirakoya-Samadoulougou, Vincent De Brouwere, Arnold Fottsoh Fokam, Mady Ouédraogo, Yazoumé Yé   +4 more
doaj   +1 more source

Medication adherence framework: A population‐based pharmacokinetic approach and its application in antimalarial treatment assessments

CPT: Pharmacometrics &Systems Pharmacology, Volume 13, Issue 5, Page 795-811, May 2024.
Abstract We reported here on the development of a pharmacometric framework to assess patient adherence, by using two population‐based approaches – the percentile and the Bayesian method. Three different dosing strategies were investigated in patients prescribed a total of three doses; (1) non‐observed therapy, (2) directly observed administration of ...
Junjie Ding, Richard M. Hoglund, Joel Tarning   +2 more
wiley   +1 more source

Women's Experiences and Views about Costs of Seeking Malaria Chemoprevention and other Antenatal Services: A Qualitative Study from two Districts in Rural Tanzania. [PDF]

, 2010
The Tanzanian government recommends women who attend antenatal care (ANC) clinics to accept receiving intermittent preventive treatment against malaria during pregnancy (IPTp) and vouchers for insecticide-treated nets (ITNs) at subsidized prices.
A Hardon, AGH Thompson, AK Hussein, AK Mbonye, B Greenwood, B Greenwood, C Boller, C Goodman, C Quijada, Department for International Development (DFID), E Torell, E Worrall, G Mubyazi, G Mubyazi, G Munishi, GB Overbosch, GM Mubyazi, GM Mubyazi, GM Mubyazi, GM Mubyazi, GM Mubyazi, Godfrey M Mubyazi, H Birungi, Ib C Bygbjerg, J Hill, J Sachs, Jens Byskov, K Hanson, K Wyss, Kristian S Hansen, M Mamdani, M Rao, Malaria Consortium, Mapping Malaria Risk in Africa (MARA), Ministry of Health, Ministry of Health, Ministry of Health-Tanzania, MJ Ribera, Pascal Magnussen, Paul Bloch, PL Olliaro, RP Shaw, T Ensor, T Mathole, TANHERF, W Newbrander, WHO, WHO, WHO, Øystein E Olsen   +49 more
core   +4 more sources

Effect of seasonal malaria chemoprevention plus azithromycin on Plasmodium falciparum transmission: gametocyte infectivity and mosquito fitness

Malaria Journal, 2021
Background Seasonal malaria chemoprevention (SMC) consists of administration of sulfadoxine-pyrimethamine (SP) + amodiaquine (AQ) at monthly intervals to children during the malaria transmission period.
Koudraogo Bienvenue Yaméogo, Rakiswendé Serge Yerbanga, Seydou Bienvenu Ouattara, Franck A. Yao, Thierry Lefèvre, Issaka Zongo, Frederic Nikièma, Yves Daniel Compaoré, Halidou Tinto, Daniel Chandramohan, Brian Greenwood, Adrien M. G. Belem, Anna Cohuet, Jean Bosco Ouédraogo   +13 more
doaj   +1 more source

Predicting malaria dynamics in Burundi using deep Learning Models [PDF]

arXiv, 2023
Malaria continues to be a major public health problem on the African continent, particularly in Sub-Saharan Africa. Nonetheless, efforts are ongoing, and significant progress has been made. In Burundi, malaria is among the main public health concerns. In the literature, there are limited prediction models for Burundi.
arxiv  

Estimation of trajectory of protective efficacy in infectious disease prevention trials using recurrent event times

Statistics in Medicine, Volume 43, Issue 9, Page 1759-1773, 30 April 2024.
In studies of infectious disease prevention, the level of protective efficacy of medicinal products such as vaccines and prophylactic drugs tends to vary over time. Many products require administration of multiple doses at scheduled times, as opposed to one‐off or continual intervention. Accurate information on the trajectory of the level of protective
Yin Bun Cheung, Xiangmei Ma, K. F. Lam, Chee Fu Yung, Paul Milligan   +4 more
wiley   +1 more source

Ex vivo drug susceptibility and resistance mediating genetic polymorphisms of Plasmodium falciparum in Bobo-Dioulasso, Burkina Faso. [PDF]

Malaria remains a leading cause of morbidity and mortality in Burkina Faso, which utilizes artemether-lumefantrine as the principal therapy to treat uncomplicated malaria and seasonal malaria chemoprevention with monthly sulfadoxine-pyrimethamine plus ...
Bailey, Jeffrey, Bazié, Thomas, Conrad, Melissa, Cooper, Roland, Fofana, Aminata, Garg, Shreeya, Kabré, Zachari, Kagambega, Tegawinde, Legac, Jenny, Neya, Catherine, Ouédraogo, Jean-Bosco, Rosenthal, Philip, Somé, A, Somé, Myreille, Yerbanga, R   +14 more
core   +1 more source

Randomized, placebo‐controlled, double‐blind phase I trial of co‐administered pyronaridine and piperaquine in healthy adults of sub‐Saharan origin

Clinical and Translational Science, Volume 17, Issue 4, April 2024.
Abstract Drug resistance to sulfadoxine‐pyrimethamine and amodiaquine threatens the efficacy of malaria chemoprevention interventions in children and pregnant women. Combining pyronaridine (PYR) and piperaquine (PQP), both components of approved antimalarial therapies, has the potential to protect vulnerable populations from severe malaria.
Andrea Kuemmerle, Denis Gossen, Annick Janin, Andrew Stokes, Nada Abla, Maja Szramowska, Ulrike Lorch, Myriam El Gaaloul, Isabelle Borghini‐Fuhrer, Stephan Chalon   +9 more
wiley   +1 more source

Impact of intermittent preventive treatment with dihydroartemisinin-piperaquine on malaria in Ugandan schoolchildren: a randomized, placebo-controlled trial. [PDF]

, 2014
BACKGROUND: Intermittent preventive treatment (IPT) in schoolchildren offers a promising option for malaria control. However, the optimal drug and dosing regimens for IPT remain to be determined.
Amuge, Pauline, Brooker, Simon, Dorsey, Grant, Kamya, Moses, Kiwanuka, Noah, Nankabirwa, Joaniter, Rosenthal, Philip, Staedke, Sarah, Wandera, Bonnie   +8 more
core   +2 more sources

Is it time for Africa to adopt primaquine in the era of malaria control and elimination?

Tropical Medicine and Health, 2022
Keypoints Sub-Saharan Africa contributes about 95% of global malaria cases and related deaths. Despite safety concerns adoption of SLD primaquine is needed to further reduce malaria transmission, an essential prerequisite for the elimination of the ...
Richard O. Mwaiswelo, Hamis Kabuga, Eliningaya J. Kweka, Vito Baraka   +3 more
doaj   +1 more source