Results 121 to 130 of about 3,965 (238)

Estimation of trajectory of protective efficacy in infectious disease prevention trials using recurrent event times

Statistics in Medicine, Volume 43, Issue 9, Page 1759-1773, 30 April 2024.
In studies of infectious disease prevention, the level of protective efficacy of medicinal products such as vaccines and prophylactic drugs tends to vary over time. Many products require administration of multiple doses at scheduled times, as opposed to one‐off or continual intervention. Accurate information on the trajectory of the level of protective
Yin Bun Cheung, Xiangmei Ma, K. F. Lam, Chee Fu Yung, Paul Milligan   +4 more
wiley   +1 more source

Randomized, placebo‐controlled, double‐blind phase I trial of co‐administered pyronaridine and piperaquine in healthy adults of sub‐Saharan origin

Clinical and Translational Science, Volume 17, Issue 4, April 2024.
Abstract Drug resistance to sulfadoxine‐pyrimethamine and amodiaquine threatens the efficacy of malaria chemoprevention interventions in children and pregnant women. Combining pyronaridine (PYR) and piperaquine (PQP), both components of approved antimalarial therapies, has the potential to protect vulnerable populations from severe malaria.
Andrea Kuemmerle, Denis Gossen, Annick Janin, Andrew Stokes, Nada Abla, Maja Szramowska, Ulrike Lorch, Myriam El Gaaloul, Isabelle Borghini‐Fuhrer, Stephan Chalon   +9 more
wiley   +1 more source

Cost-effectiveness of district-wide seasonal malaria chemoprevention when implemented through routine malaria control programme in Kita, Mali using fixed point distribution [PDF]

, 2021
Halimatou Diawara, Patrick Walker, Matt Cairns, Laura C. Steinhardt, Fatou Diawara, Beh Kamaté, Laeticia Duval, Elisa Sicuri, Issaka Sagara, Aboubacar Sadou, Jules Mihigo, Erin Eckert, Alassane Dicko, Lesong Conteh   +13 more
openalex   +1 more source

Strengthening malaria control through seasonal malaria chemoprevention campaign in Guinea-Bissau

, 2017
In Guinea-Bissau, malaria is the leading morbidity and cause of mortality due to diseases in children under 5 years old. To reduce this, MSF has designed the Seasonal Malaria Chemoprevention (SMC) in the Bafatá region of Guinea-Bissau. This implementation was the first in Guinea-Bissau to have a good outcome, and MSF has trained staff in other regions ...
Rocaspana, Mercè, Dakitche Lawoe Houedakor, Villen, Susana   +2 more
openaire   +1 more source

Beninese Plant Extracts with Antiplasmodial Activity Select New Allele Variants Msp1 and Msp2 in Plasmodium falciparum

Journal of Parasitology Research, Volume 2024, Issue 1, 2024.
Background. Natural medicinal products are commonly used as a remedy against malaria infections in African populations and have become a major source of information for the screening of new and more effective antiplasmodial molecules. Therefore, in vitro studies are needed to validate the efficacy of these medicinal products and to explore the ...
Hamirath O. Lagnika, Adandé A. Medjigbodo, Oswald Y. Djihinto, Helga M. Saïzonou, Wassiyath A. Mousse, Romaric Akoton, Laurette Djossou, Doris N. Vodounkpe, Latifou Lagnika, Luc S. Djogbénou, Bernard Marchand   +10 more
wiley   +1 more source

Rethinking a hybrid malaria chemoprevention delivery strategy for children in sub-perennial settings: a modelling study integrating age- and seasonally-targeted delivery

Malaria Journal
Background The World Health Organization recommends perennial malaria chemoprevention (PMC), generally using sulfadoxine-pyrimethamine (SP) to children at high risk of severe Plasmodium falciparum malaria.
Swapnoleena Sen, David Schellenberg, Melissa A. Penny   +2 more
doaj   +1 more source

Malaria Prevention Strategies in South Sudan

South Sudan Medical Journal, 2020
The whole of South Sudan is endemic for malaria, with high transmission in the country throughout the year. Malaria is the leading cause of illness and death in children under five years. In 2019, the malaria incidence (all ages) was estimated at 246 per
Harriet Akello Pasquale
doaj  

Reactive community-based self-administered treatment against residual malaria transmission: study protocol for a randomized controlled trial [PDF]

, 2018
Background: Systematic treatment of all individuals living in the same compound of a clinical malaria case may clear asymptomatic infections and possibly reduce malaria transmission, where this is focal.
A Kaneko, A Tynan, AB Tiono, BR Carter, C Smith Gueye, CE Strachan, Davis Nwakanma, E Poirot, EC Oriero, Fatou Jaiteh, G Newby, GH Stresman, Global Malaria Programme, GM Raab, HJ Sturrock, J Hustedt, J Mwesigwa, JAM Atkinson, Joan Muela Ribera, John Bradley, Joseph Okebe, Julie Balen, KA Lindblade, KM Searle, Koen Peeters Grietens, L von Seidlein, LL van den Hoogen, M Littrell, M Pinder, ME Rutherford, MJ Kirby, N Hofmann, NJ Dial, R Daniels, RC Tine, S Dierickx, SE Kern, Shunmay Yeung, SJ Ceesay, T Bousema, Umberto D’Alessandro, World Health Organization (WHO), Yoriko Masunaga   +42 more
core   +3 more sources

COVID-19 knowledge, beliefs, prevention behaviours and misinformation in the context of an adapted seasonal malaria chemoprevention campaign in six northern Nigerian States [PDF]

, 2020
Sol Richardson, Taiwo Ibinaiye, Jamilu Nikau, Olusola Oresanya, Madeleine Marasciulo, Arantxa Roca‐Feltrer, Christian Rassi, Olatunde Adesoro   +7 more
openalex   +1 more source

Age‑shifting in malaria incidence as a result of induced immunological deficit: a simulation study [PDF]

, 2015
Effective population-level interventions against Plasmodium falciparum malaria lead to age-shifts, delayed morbidity or rebounds in morbidity and mortality whenever they are deployed in ways that do not permanently interrupt transmission.
Hodel, Eva Maria
core   +1 more source