Results 71 to 80 of about 269,580 (290)

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Effect of a Carbohydrate-Electrolyte Solution on Fluid Balance and Performance at a Thermoneutral Environment in International-Level Fencers [PDF]

, 2020
© 2019 by the National Strength & Conditioning Association.Chryssanthopoulos, C, Tsolakis, C, Bottoms, L, Toubekis, A, Zacharogiannis, E, Pafili, Z, and Maridaki, M.
Bottoms, Lindsay, Chryssanthopoulos, Costas, Maridaki, Maria, Pafili, Zoi, Toubekis, Argyris, Tsolakis, Charis, Zacharogiannis, Elias   +6 more
core   +2 more sources

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

THE RELATIONSHIP BETWEEN HEART RATE VARIABILITY AND ATHLETIC PERFORMANCE IN BASKETBALL PLAYERS

Türk Fizyoterapi ve Rehabilitasyon Dergisi
Purpose: For basketball players, improving athletic performance is one of the main keys to success and the autonomic nervous system can also affect athletic performance. Heart rate variability (HRV) can be associated with sportive performance as a marker
Burak KARAHAN, Hilal ASLAN, Emre UYSAL, Rabia Tuğba TEKİN   +3 more
doaj   +1 more source

Fuzzy logic based intention recognition in STS processes [PDF]

, 2017
This paper represents a fuzzy logic based classifier that is able to recognise human users' intention of standing up from their behaviours in terms of the force they apply to the ground.
Li, Dayou, Lu, Hang, Qiu, Renxi
core   +2 more sources

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Robot-Based Assessment of Sitting Balance: Muscular Responses to Self- and Externally-Controlled Perturbations in Seated Position

IEEE Access
In the field of rehabilitation, traditional methods for assessing and training core stability and trunk control involve exercises targeting breathing, muscle strengthening, and both static and dynamic balance.
G. Marchesi, V. Squeri, A. Bellitto, G. Pinna, C. Pierella, A. Canessa, A. de Luca, M. Casadio   +7 more
doaj   +1 more source

An efficient workflow to accurately compute groundwater recharge for the study of rainfall-triggered deep-seated landslides, application to the Séchilienne unstable slope (western Alps) [PDF]

Hydrology and Earth System Sciences, 2015
Pore water pressure build-up by recharge of underground hydrosystems is one of the main triggering factors of deep-seated landslides. In most deep-seated landslides, pore water pressure data are not available since piezometers, if any, have a very short ...
A. Vallet, C. Bertrand, O. Fabbri, J. Mudry   +3 more
doaj   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source