Results 91 to 100 of about 21,379 (299)

Icariin Enhances the Enzymatic Activity of N‐acetylgalactosaminidase to Augment Akkermansia Abundance in Gut Microbiota for Improved PD‐1 Blockade Efficacy in Tumor Suppression

Advanced Science, EarlyView.
Icariin promoted the growth of Akk by enhancing the activity of N‐acetylgalactosaminidase (Amuc_0920), which enhanced mucin utilization and provided a favorable nutrient environment for bacterial growth. This icariin‐mediated enrichment of Akk further reshaped the tumor microenvironment and promoted CD8+ T cell infiltration, ultimately synergizing with
Shuangying Qiao, Liu Yang, Haibang Hao, Qiuxia Ding, Feng Ding, Zheng Chen, Jinfang Zhang, Yun He, Meng Li, Jun Xu, Chao Wang, Aiping Lu, Fangfei Li   +12 more
wiley   +1 more source

Differentiation between chalazion and sebaceous carcinoma by noninvasive meibography

Clinical Ophthalmology, 2014
Yuji Nemoto,1 Reiko Arita,2,3 Atsushi Mizota,1 Yuko Sasajima4 1Department of Ophthalmology, Teikyo University School of Medicine, Tokyo, 2Itoh Clinic, Saitama, 3Department of Ophthalmology, The University of Tokyo, Tokyo, 4Department of Pathology ...
Nemoto Y, Arita R, Mizota A, Sasajima Y
doaj  

NUP85 Mediates Endoplasmic Reticulum Stress through the USP47/ASK1 Signaling Pathway to Regulate the Progression of Liver Fibrosis

Advanced Science, EarlyView.
In the present study, we have demonstrated that the NUP85‐USP47‐ASK1 signaling pathway may have regulated the progression of liver fibrosis through modulating ERS. Additionally, we have developed a CREKA‐coupled liposome to target delivery of MV, a pharmacological inhibitor of NUP85, to activated HSCs, thereby attenuating liver fibrosis. ABSTRACT Liver
Dashuai Yang, Haoran Yang, Linxin Pan, Chang Tian, Fucheng Zuo, Shilei Huang, Xianrui Li, Ming Chen, Cheng Qian, Jie Wang, Zhaolin Chen, Tao Xu   +11 more
wiley   +1 more source

p63 expression in normal skin and usual cutaneous carcinomas [PDF]

, 2002
Background: p63 is a p53 homologue that is mapped to chromosome 3q27. This gene encodes six different isoforms, which have either transactivating or dominant negative effects on p53-reporter genes. It has been described that in contrast to p53, p63 seems
André Albergaria, Barbareschi, Barrett, Beatriz Torio, Bockmuhl, Broders, Cho, De Laurenzi, Di Como, Fernando C. Schmitt, Hibi, Jorge S. Reis-Filho, Kaufmann, Levrero, Mills, Noszczyk, Nylander, Nylander, Parsa, Pellegrini, Reis-Filho, Rippey, Signoretti, Yamaguchi, Yang   +24 more
core   +3 more sources

Accuracy of mobile digital teledermoscopy for skin self-examinations in adults at high risk of skin cancer: an open-label, randomised controlled trial [PDF]

, 2020
Background: Skin self-examinations supplemented with mobile teledermoscopy might improve early detection of skin cancers compared with naked-eye skin self-examinations.
Avilés-Izquierdo, Baade, Berwick, Boyce, Chambers, Chao, Djaja, Genders, Hamidi, Janda, Janda, Janda, Kandel, King, Kroemer, Li, Luttrell, Manahan, Markun, Morze, Pike, Rat, Robinson, Tschandl, Venables, Wu   +25 more
core   +1 more source

N4‐acetylcytidine in LncRNA Gm26917 Promotes Translation in Female Germline Stem Cells by Recruiting Ribosomal Protein mRNA via EEF1A1

Advanced Science, EarlyView.
This work establishes that ac4C modification on lncRNA Gm26917 governs its spatial interactions with Rpl10 mRNA, and RBP EEF1A1 mediates the interaction between Gm26917 and Rpl10. It elucidates a novel ac4C‐Gm26917‐EEF1A1‐Rpl10 axis in FGSC maintenance both in vitro and in vivo, and provides a potential molecular target for modulating germ cell ...
Xinyue Li, Xiaopeng Hu, Ji Wu
wiley   +1 more source

Sebaceous carcinoma arising within an ovarian mature cystic teratoma: A case report with discussion of clinical management and genetic evaluation

Gynecologic Oncology Reports, 2018
Sebaceous carcinomas are rare tumors, with the majority of described cases occurring within the eyelid. To date, there are nine documented reports of sebaceous carcinoma arising within a mature cystic teratoma of the ovary. Although the majority of cases
Alyssa Wield, Melissa Hodeib, Mohammad Khan, Lindsay Gubernick, Andrew J. Li, Shivani Kandukuri   +5 more
doaj   +1 more source

Beyond Transconductance: Cell‐Polymer Coupling Determines Fidelity in Action Potential Recording via Electrolyte‐Gated Polymer Transistors

Advanced Science, EarlyView.
High electrical performance alone does not guarantee efficient bioelectronic signal transduction. Despite excellent mixed ionic‐electronic conduction, recordings from cardiomyocytes reveal that p(g2T‐TT)‐based OECTs predominantly transduce field potential FP‐like signals due to weak cell‐polymer coupling.
Giulia Zoe Zemignani, Elena Mancinelli, Gabriele Tullii, Aleksandr Khudiakov, Cristiano Bortolotti, Shubham Tanwar, Peter J. Schwartz, Luca Sala, Maria Rosa Antognazza, Mario Caironi, Adrica Kyndiah   +10 more
wiley   +1 more source

Sebaceous carcinoma : a case report [PDF]

, 2018
El carcinoma de células sebáceas es un tumor maligno infrecuente de la piel. Se lo clasifica en ocular y extraocular. Su importancia radica en su agresividad con altas tasas de recurrencia y metástasis.
Abaca, María Celeste, Cantú Parra, Laura, Fernandez Tapia, María, Innocenti, Alicia Carolina, Vidal, Jorgelina Natalí   +4 more
core  

Integrating Spatial Proteogenomics in Cancer Research

Advanced Science, EarlyView.
Xx xx. ABSTRACT Background: Spatial proteogenomics marks a paradigm shift in oncology by integrating molecular analysis with spatial information from both spatial proteomics and other data modalities (e.g., spatial transcriptomics), thereby unveiling tumor heterogeneity and dynamic changes in the microenvironment.
Yida Wang, Yang Wu, Feng Zhang, Parthiban Periasamy, Haiyue You, Denise Goh, Rachel Elizabeth Ann Fincham, Xin Ning, Danping Wu, Lu Liu, Ying Jiang, Zhiwen Qian, Joe Yeong, Yan Zhang   +13 more
wiley   +1 more source