Results 21 to 30 of about 13,963,189 (308)

Second-line drug therapy for osteoarthritis [PDF]

Clinical Medicine, 2001
L'activite biologique des medicaments antibiotiques ou antiinflammatoires destines a traiter l'osteite est decrite, ainsi que leurs effets ...
openaire   +2 more sources

Phase I/II trial of meclofenamate in progressive MGMT-methylated glioblastoma under temozolomide second-line therapy—the MecMeth/NOA-24 trial

Trials, 2022
Background Glioblastoma is the most frequent and malignant primary brain tumor. Even in the subgroup with O-6-methylguanine-DNA methyltransferase (MGMT) promoter methylation and favorable response to first-line therapy, survival after relapse is short ...
Thomas Zeyen, Anna-Laura Potthoff, Robert Nemeth, Dieter H. Heiland, Michael C. Burger, Joachim P. Steinbach, Peter Hau, Ghazaleh Tabatabai, Martin Glas, Uwe Schlegel, Oliver Grauer, Dietmar Krex, Oliver Schnell, Roland Goldbrunner, Michael Sabel, Niklas Thon, Daniel Delev, Hans Clusmann, Clemens Seidel, Erdem Güresir, Matthias Schmid, Patrick Schuss, Frank A. Giordano, Alexander Radbruch, Albert Becker, Johannes Weller, Christina Schaub, Hartmut Vatter, Judith Schilling, Frank Winkler, Ulrich Herrlinger, Matthias Schneider   +31 more
doaj   +1 more source

Cabozantinib for the Management of Metastatic Clear Cell Renal Cell Carcinoma

Journal of Kidney Cancer and VHL, 2018
Cabozantinib is a multi-tyrosine kinase inhibitor used for the treatment of various solid-organ tumours. It was recently approved as a first- and second-line therapeutic for the management of advanced/metastatic renal cell carcinoma based on the results ...
Sharon Del Vecchio, Robert J Ellis
doaj   +1 more source

Phage Therapy Potentiates Second-Line Antibiotic Treatment against Pneumonic Plague

Viruses, 2022
Plague pandemics and outbreaks have killed millions of people during the history of humankind. The disease, caused by the bacteria Yersinia pestis, is currently treated effectively with antibiotics.
Yaron Vagima, David Gur, Moshe Aftalion, Sarit Moses, Yinon Levy, Arik Makovitzki, Tzvi Holtzman, Ziv Oren, Yaniv Segula, Ella Fatelevich, Avital Tidhar, Ayelet Zauberman, Shahar Rotem, Emanuelle Mamroud, Ida Steinberger-Levy   +14 more
doaj   +1 more source

Second line therapy in type 2 diabetes: legacy effect activation

Сахарный диабет, 2017
Type 2 diabetes causes hundred thousand deaths worldwide every year. Though new antidiabetic drugs appear annually and new classes of drugs are invented approximately every ten years still a lot of type 2 diabetic patients remain to be out of the target ...
Ekaterina A. Shestakova
doaj   +1 more source

Glioblastoma treatment patterns, survival, and healthcare resource use in real-world clinical practice in the USA

Drugs in Context, 2015
Background: Glioblastoma (GB) treatment remains challenging because of recurrence and poorly defined treatment options after first-line therapy. To better understand real-world application of treatment paradigms and their impact on outcomes, we describe ...
Allicia C Girvan, Gebra C Carter, Li Li, Anna Kaltenboeck, Jasmina Ivanova, Maria Koh, Jessi Stevens, Eleanor Hayes-Larson, Michael M Lahn   +8 more
doaj   +1 more source

Second-Line Therapy in Pancreatic Cancer

JOP : Journal of the pancreas, 2013
At the time of diagnosis most of patients present with advanced or metastatic pancreatic cancer, thereby precluding surgical resection. While the standard of care in the first line setting is established, there are limited data to support a standard second-line chemotherapy regimen.
Evangelia, Skoura, Konstantinos N, Syrigos, Muhammad Wasif, Saif   +2 more
openaire   +2 more sources

Second-Line Antiretroviral Therapy [PDF]

JAIDS Journal of Acquired Immune Deficiency Syndromes, 2012
Currently, boosted protease inhibitor-containing regimens are the only option after first-line regimen failure available for patients in most resource-limited settings, yet little is known about long-term adherence and outcomes.We enrolled patients with virologic failure (VF) who initiated lopinavir/ritonavir-containing second-line antiretroviral ...
Richard A, Murphy, Henry, Sunpath, Carmen, Castilla, Shameez, Ebrahim, Richard, Court, Hoang, Nguyen, Daniel, Kuritzkes, Vincent C, Marconi, Jean B, Nachega   +8 more
openaire   +2 more sources

Pediatric response to second-line antiretroviral therapy in South Africa. [PDF]

PLoS ONE, 2012
With improved access to pediatric antiretroviral therapy (ART) in resource-limited settings, more children could experience first-line ART treatment failure.We performed a retrospective cohort analysis using electronic medical records from HIV-infected ...
Brian C Zanoni, Henry Sunpath, Margaret E Feeney   +2 more
doaj   +1 more source

Rates and Predictors of Failure of First-line Antiretroviral Therapy and Switch to Second-line ART in South Africa [PDF]

, 2012
To measure rates and predictors of virologic failure and switch to second-line antiretroviral therapy (ART) in South ...
Olivia Keiser, Giddy, Janet, Egger, Matthias, Maskew, Mhairi, Hans Prozesky, Sterne, Jonathan A C, Janet Giddy, Hernán, Miguel A., Miguel A. Hernán, for the IeDEA-SA collaboration,, Robin Wood, Fox, Matthew P, Gilles Van Cutsem, Matthias Egger, Keiser, Olivia, van Cutsem, Gilles, Hernán, Miguel A, Jonathan A. C. Sterne, Fox, Matthew P., Mhairi Maskew, Cutsem, Gilles Van, Prozesky, Hans, Boulle, Andrew, Matthew P. Fox, Andrew Boulle, Wood, Robin, Sterne J.A.C., Giddy J., Maskew M., Egger M., Fox M.P., Cutsem G.V., Prozesky H., Hernan M.A., Boulle A., Keiser O., Wood R.   +36 more
core   +3 more sources