Results 101 to 110 of about 19,188,679 (307)

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Treatment of metastatic breast cancer: second line and beyond

Annals of Oncology, 2011
Increasing use of standard chemotherapy, especially anthracycline- and taxane-based therapies, in early-stage breast cancer has led to a corresponding increase in heavily pretreated and/or treatment-resistant cases of metastatic breast cancer (MBC). Thus, second and later lines of MBC therapy frequently involve the clinically challenging picture of ...
H, Roché, L T, Vahdat
openaire   +2 more sources

The association between effectiveness of first-line treatment and second-line treatment in gastro- oesophageal cancer

, 2021
Background: Population-based predictive factors for the effectiveness of second line palliative systemic therapy in gastro-oesophageal cancer are not available.
Velzen, M.J.M. van, Laarhoven, H.W.M. van, Creemers, G.J., Derks, S., Pape, M., Mohammad, N.H., Dijksterhuis, W.P.M., Slingerland, M., Verhoeven, R.H.A., Voorthuizen, T. van, Beerepoot, L.V., Marieke Pape, Rob H.A. Verhoeven, Geert-Jan Creemers, Laurens V. Beerepoot, Merel J.M. van Velzen, Willemieke P.M. Dijksterhuis, Marije Slingerland, Nadia H. Mohammad, Sarah Derks, Theo van Voorthuizen, Hanneke W.M. van Laarhoven   +21 more
core   +1 more source

L‐aspartate oxidase provides new insights into fumarate reduction in anaerobic darkness in Synechocystis sp. PCC6803

FEBS Letters, EarlyView.
Synechocystis strains deficient in succinate dehydrogenase (SDH) secrete more succinate than the WT under dark anaerobic conditions, supporting that SDH then primarily acts as SDH, not as a fumarate reductase. L‐aspartate oxidase (Laspo) from Synechocystis is functional under anaerobic conditions, reducing fumarate to succinate.
Kateryna Kukil, Jeffrey A. Hawkes, Cecilia Blikstad, Pia Lindberg   +3 more
wiley   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Statistical analysis on the incidence and predictors of death among second-line ART patients in public hospitals of North Wollo and Waghemira Zones, Ethiopia, 2021

Scientific Reports
Acquired immune deficiency virus, caused by the human immunodeficiency virus, is a significant global health concern. Sub-Saharan Africa particularly Ethiopia faces a high prevalence of human immunodeficiency virus.
Atitegeb Abera Kidie, Seteamlak Adane Masresha, Fassikaw Kebede Bizuneh   +2 more
doaj   +1 more source

Targeted Second-Line Treatment [PDF]

Deutsches Ärzteblatt international, 2010
Jantsch, Jonathan, Bogdan, Christian
openaire   +1 more source

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

Second-line treatment of hepatocellular carcinoma: from theory to practical issues

Медицинский совет, 2019
Hepatocellular carcinoma (HCC) is the most frequent primary liver cancer with unmet needs of effective medications. Lenvatinib – a new oral multikinase inhibitor (MKI) proved to be as effective as sorafenib in terms of survival has been added recently to
V. V. Breder, K. K. Laktionov
doaj   +1 more source

Second-line HIV treatment failure in sub-Saharan Africa: A systematic review and meta-analysis [PDF]

, 2019
BackgroundIncreased second-line antiretroviral therapy (ART) failure rate narrows future options for HIV/AIDS treatment. It has critical implications in resource-limited settings; including sub-Saharan Africa (SSA) where the burden of HIV-infection is ...
Mekonnen Sisay (5594804), Kumsa, F, Mekonnen Sisay, Fekede Asefa (7053857), Fekede Asefa, Dumessa Edessa (792901), Edessa, D, Dumessa Edessa, Sisay, M   +8 more
core   +1 more source