Results 91 to 100 of about 19,188,679 (307)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Second-line treatment of advanced non-small cell lung cancer

, 2008
After failure of first-line chemotherapy for advanced non-small cell lung cancer, many patients remain candidates to receive further antitumor treatment.
De Petris, Luigi, Ciardiello, Fortunato, Gridelli, Cesare, Di Maio, Massimo, Thatcher, Nick, De Marinis, Filippo, Hanna, Nasser, Rosell, Rafael, Vansteenkiste, Johan, Perrone, Francesco, Perrone F, Heymach, JV, Ciardiello, F, Gridelli C, Heymach JV, Rosell R, Shepherd, Frances A, Ardizzoni, A, Hanna N, Di Maio M, De Marinis F., Vansteenkiste J, Thatcher N, Perrone, F, Shepherd, FA, Gridelli, C, De Petris L, Hanna, N, Ciardiello F, Rosell, R, Heymach, John V, Shepherd FA, Thatcher, N, Vansteenkiste, J, ARDIZZONI, ANDREA   +34 more
core   +2 more sources

Time to Treatment Failure and Its Predictors Among Second-Line ART Clients in Amhara Region, Ethiopia: A Retrospective Follow-Up Study [PDF]

Habtamu Wagnew Abuhay,1 Tizazu Endalew,2 Tilahun Yemanu Birhan,1,* Achenef Asmamaw Muche1,* 1Department of Epidemiology and Biostatistics, Institute of Public Health, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia;
Abuhay HW, Muche AA, Endalew T, Birhan TY   +3 more
core  

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Effectiveness and tolerability of second-line treatment with vildagliptin versus other oral drugs for type 2 diabetes in a real-world setting in the Middle East: results from the EDGE study

Vascular Health and Risk Management, 2015
Charles Saab,1 Feryal A Al-Saber,2 Jihad Haddad,3 Mahir Khalil Jallo,4 Habib Steitieh,5 Giovanni Bader,6 Mohamed Ibrahim,7 1Department of Endocrinology and Metabolism, Sacre Coeur University Hospital, Baabda, Lebanon; 2Endocrine Department, Bahrain ...
Saab C, Al-Saber FA, Haddad J, Jallo MK, Steitieh H, Bader G, Ibrahim M   +6 more
doaj  

LEFLUNOMIDE AS A POTENTIAL SECOND-LINE DRUG IN THE TREATMENT OF SARCOIDOSIS

TUBERCULOSIS AND LUNG DISEASES, 2019
Sarcoidosis is systemic granulomatosis of an unknown nature, the course of which varies from spontaneous remission to progression resulting in failure of organs and systems. The article presents a review of current approaches to treatment of sarcoidosis putting special emphasis on the use of the anti-rheumatic drug of leflunomide (LEF).
A. A. Vizel, I. Yu. Vizel
openaire   +3 more sources

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

A Multicenter Retrospective Study: Impact of First-Line Treatment Strategies on second-Line Efficacy and Safety of Regorafenib with or Without PD-1 Inhibitors in Unresectable Hepatocellular Carcinoma

Journal of Hepatocellular Carcinoma
Weihong Ma,1,2,* Yinyin Li,1,* Yinying Lu,1,2 Zhipeng Liang,3 Hongli Yu,1,2 Jie Han,1,2 Jiaqi Liu,1,2 Wenjing Wang,1,2 Caiyun Peng,1 Jiamin Cheng1 1Senior Department of Hepatology, The 5th Medical Center of the PLA General Hospital ...
Ma W, Li Y, Lu Y, Liang Z, Yu H, Han J, Liu J, Wang W, Peng C, Cheng J   +9 more
doaj  

HIV drug resistance and third line treatment outcomes in patients failing: Protease Inhibitor based second-line antiretroviral therapy in Zimbabwe

, 2020
Introduction: We set out to assess the distribution of HIV drug resistance mutations and their risk factors in patients failing 2nd line ART and to determine treatment outcomes among patients receiving 3rd line ART in Zimbabwe.
Chimbetete, Cleophas
core   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source