Results 71 to 80 of about 19,188,679 (307)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

HIV drug resistance, early treatment outcomes and impact of guidelines compliance after protease inhibitor‐based second‐line failure in a dedicated resistance clinic in western Kenya: a retrospective cohort study

Journal of the International AIDS Society
Introduction Data on drug resistance, viral outcomes and guidelines compliance following protease inhibitor (PI)‐based second‐line failure in low‐ and middle‐income countries are limited, particularly in the era of dolutegravir‐containing antiretroviral ...
John M. Humphrey, Shamim M. Ali, Allison DeLong, Vlad Novitsky, Edwin Sang, Bilal Jawed, Emmanuel Kemboi, Celia Ngetich, Suzanne Goodrich, Adrian Gardner, Joseph W. Hogan, Rami Kantor   +11 more
doaj   +1 more source

Percent of individuals starting partially inactive second-line treatment due to acquired drug resistance during first-line treatment.

, 2012
Percent of individuals starting partially inactive second-line treatment due to acquired drug resistance during first-line treatment.
Valentina Cambiano (146513), Deenan Pillay (7888), Silvia Bertagnolio (57174), Michael R. Jordan (146520), Andrew N. Phillips (146556), Alec Miners (146534), Jens Lundgren (146550), Viktor von Wyl (146506)   +7 more
core   +1 more source

Clinical potential of nintedanib for the second-line treatment of advanced non-small-cell lung cancer: current evidence [PDF]

, 2014
Sacha I Rothschild Department of Internal Medicine, Medical Oncology, University Hospital Basel, Basel, Switzerland Abstract: The therapeutic landscape in non-small-cell lung cancer (NSCLC) is changing.
Rothschild SI
core   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Clinical use of alprostadil topical cream in patients with erectile dysfunction: a review

Research and Reports in Urology, 2016
James Anaissie, Wayne JG Hellstrom Department of Urology, Tulane University School of Medicine, New Orleans, LA, USA Abstract: Erectile dysfunction (ED) is a common and debilitating disorder seen in over 50% of men older than 70 years.
Anaissie J, Hellstrom WJG
doaj  

Second-line treatment initiation within 6 mo, time to treatment, and site of treatment initiation by age, sex, HIV status, diagnostic facility, and diagnostic test (new rifampicin-resistant tuberculosis patients, 2013 cohort).

, 2017
Second-line treatment initiation within 6 mo, time to treatment, and site of treatment initiation by age, sex, HIV status, diagnostic facility, and diagnostic test (new rifampicin-resistant tuberculosis patients, 2013 cohort).
Norbert Ndjeka (3768898), Anja van’t Hoog (300467), Helen Cox (66086), Lindy Dickson-Hall (3768895), Alison Grant (790918), Frank Cobelens (109566), Mark Nicol (3498533), Wendy Stevens (62288)   +7 more
core   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Second-line systemic treatment for advanced cholangiocarcinoma.

, 2014
371 Background: Five-year survival for advanced cholangiocarcinoma (aCC) is reported at 5-10%. For advanced, unresectable patients, gemcitabine plus platinum (GEM-P) combination chemotherapy is common practice as first-line treatment with progression ...
Ahmed Omar Kaseb, Rachna T. Shroff, Lindsey Law, D. Van Nguyen, Jane Elizabeth Rogers, Wei Qiao, Milind M. Javle   +6 more
core   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source