Results 71 to 80 of about 681,822 (281)
Data in Brief, 2019 This article contains intensity and aversiveness ratings of electrical stimuli and data on electrodermal activity (skin conductance level and skin conductance response) during an implicit conditioning procedure.
Anne-Kathrin Bräscher +1 more
doaj +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
A Bio-Logical Theory of Animal Learning [PDF]
, 2009 This article provides the foundation for a new predictive theory of animal learning that is based upon a simple logical model. The knowledge of experimental subjects at a given time is described using logical equations.
A Blaisdell +32 more
core +2 more sources
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Neural Dynamics Underlying Impaired Autonomic and Conditioned Responses Following Amygdala and Orbitofrontal Lesions [PDF]
, 2007 A neural model is presented that explains how outcome-specific learning modulates affect, decision-making and Pavlovian conditioned approach responses. The model addresses how brain regions responsible for affective learning and habit learning interact ...
Bullock, Daniel +2 more
core +1 more source
From extinction learning to anxiety treatment: mind the gap [PDF]
, 2019 Laboratory models of extinction learning in animals and humans have the potential to illuminate methods for improving clinical treatment of fear-based clinical disorders.
Carpenter, Joseph K. +2 more
core +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Nuclear Materials and Energy, 2017 By application of a horizontal magnetic field, BH, with 0.3% against a toroidal magnetic field, BT, electron cyclotron wall conditioning (ECWC) plasmas produced by 2nd-harmonic X-mode (X2-mode) EC waves expand radially toward the inner wall, which is to ...
Masakatsu Fukumoto +5 more
doaj +1 more source
SECOND ORDER OPTIMALITY CONDITIONS
Doklady Belorusskogo gosudarstvennogo universiteta informatiki i radioèlektroniki, 2019 Nonlinear programming problems are studied. Necessary second order optimality conditions are proved under minimal assumptions about constraints.
A. E. Leschov, L. I. Minchenko
openaire +1 more source