Results 71 to 80 of about 100,213 (248)

Roles of aminergic neurons in formation and recall of associative memory in crickets

open access: yesFrontiers in Behavioral Neuroscience, 2010
We review recent progress in the study of roles of octopaminergic (OA-ergic) and dopaminergic (DA-ergic) signaling in insect classical conditioning, focusing on our studies on crickets.
Makoto Mizunami, Yukihisa Matsumoto
doaj   +1 more source

Second-Order Conservative Schemes and the Entropy Condition [PDF]

open access: yesMathematics of Computation, 1985
We consider numerical approximations to solutions of systems of hyperbolic conservation laws of the form ∂
openaire   +2 more sources

Reconstructing enzyme evolution by protein engineering

open access: yesFEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler   +2 more
wiley   +1 more source

Editorial: Higher-Order Conditioning: Beyond Classical Conditioning

open access: yesFrontiers in Behavioral Neuroscience, 2022
Arnau Busquets-Garcia, Nathan M. Holmes
doaj   +1 more source

Assessing thought conditioning: investigating measurement approaches and the impact of higher-order conditioning

open access: yesActa Psychologica
Recent studies suggest that thought content can be shaped through Pavlovian procedures. This experimental study aimed to investigate whether conditioned reports of thought content can be detected using alternative measures beyond rating scales, including
Thierry Kosinski   +2 more
doaj   +1 more source

'Man is the Measure of All Things'

open access: yesFootprint, 2019
The term Man, and the humanist tradition which followed from it, have been challenged in feminist, queer, poststructuralist, and postcolonial critiques, which questioned its nature, or even pondered if we are actually human. What we seek in this issue of
Victor Muñoz Sanz, Dan Handel
doaj   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

open access: yesFEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi   +6 more
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

open access: yesFEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj   +3 more
wiley   +1 more source

Profiling mouse behavior with computational tools to assess age-dependent differences in associative learning

open access: yesCell Reports: Methods
Summary: Second-order conditioning (SOC) enables animals to form associations between stimuli without direct reinforcement. In this study, we present a behavioral analysis pipeline that combines a light-tone SOC paradigm in mice with tools such as ...
Marc Canela-Grimau   +2 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

open access: yesMolecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

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