Results 71 to 80 of about 14,708,080 (276)
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
Fear conditioning- and extinction-induced neuronal plasticity in the mouse amygdala [PDF]
, 2009 Experience-dependent changes in behavior are mediated by long-term functional modifications in brain circuits. To study the underlying mechanisms, our lab is using classical auditory fear conditioning, a simple and robust form of associative learning. In
Ciocchi, Stéphane
core +1 more source
Acta PsychologicaRecent studies suggest that thought content can be shaped through Pavlovian procedures. This experimental study aimed to investigate whether conditioned reports of thought content can be detected using alternative measures beyond rating scales, including
Thierry Kosinski +2 more
doaj +1 more source
'Man is the Measure of All Things'
Footprint, 2019 The term Man, and the humanist tradition which followed from it, have been challenged in feminist, queer, poststructuralist, and postcolonial critiques, which questioned its nature, or even pondered if we are actually human. What we seek in this issue of
Victor Muñoz Sanz, Dan Handel
doaj +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Cell Reports: MethodsSummary: Second-order conditioning (SOC) enables animals to form associations between stimuli without direct reinforcement. In this study, we present a behavioral analysis pipeline that combines a light-tone SOC paradigm in mice with tools such as ...
Marc Canela-Grimau +2 more
doaj +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Energy Reports, 2018 Air conditioning systems accountable a huge amount of energy consumption, the purpose of this work is to inspect the energy efficiency and the economic impact for air-conditioners using Wireless Sensing and Actuator Networks.
Abdel-Rahman Al-Qawasmi, I. Tlili
doaj +1 more source
SECOND‐ORDER SCHEDULES AND THE PROBLEM OF CONDITIONED REINFORCEMENT [PDF]
Journal of the Experimental Analysis of Behavior, 1971 Thirteen pigeons were exposed to a variety of second‐order schedules in which responding under a component schedule was reinforced according to a schedule of reinforcement. Under different conditions, completion of each component resulted in either (1) the brief presentation of a stimulus also present during reinforcement (pairing operation), (2) the ...
openaire +2 more sources