Results 51 to 60 of about 14,708,080 (276)

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Second-order threat conditioning in the amygdala-posterior piriform cortex network

Communications Biology
Fear, while crucial for survival, is a component of a myriad of psychiatric illnesses in its extreme. Persistent fear memories can form through processes such as second-order conditioning (SOC), during which a second-order conditioned stimulus (CS2 ...
Tayebeh Sepahvand, Tian Qin, Zia Hasan, Kyron D. Power, Samantha J. Carew, Negar Nazari, Alyssa M. Janes, Ali Salman, Yue Xia, Touati Benoukraf, Qi Yuan   +10 more
doaj   +1 more source

Mechanism and Parameter Optimization of Fenton's Reagent Integrated with Surfactant Pretreatment to Improve Sludge Dewaterability. [PDF]

PLoS ONE, 2017
Sludge dewatering can effectively reduce the volume and mass of sludge for subsequent treatment and disposal. The work validated the potential of Fenton's reagent combined with dodecyl dimethyl benzyl ammonium chloride (DDBAC) in improving sludge ...
Yi Xing, Zhiqiang Wang, Chen Hong, Qiang Yang, Lihui Feng, Mengmeng Jia, Yifei Li   +6 more
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Parallel olfactory processing in the honey bee brain: odor learning and generalization under selective lesion of a projection neuron tract

Frontiers in Integrative Neuroscience, 2016
The function of parallel neural processing is a fundamental problem in Neuroscience, as it is found across sensory modalities and evolutionary lineages, from insects to humans.
Julie eCarcaud, Julie eCarcaud, Martin eGiurfa, Jean-Christophe eSandoz   +3 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Bumblebee social learning outcomes correlate with their flower-facing behaviour

Animal Cognition
Previous studies suggest that social learning in bumblebees can occur through second-order conditioning, with conspecifics functioning as first-order reinforcers.
Yuyi Lu, Zhenwei Zhuo, Mark Roper, Lars Chittka, Cwyn Solvi, Fei Peng, Ying Zhou   +6 more
doaj   +1 more source

Factorial Experiments of Soil Conditioning for Earth Pressure Balance Shield Tunnelling in Water-Rich Gravel Sand and Conditioning Effects’ Prediction Based on Particle Swarm Optimization–Relevance Vector Machine Algorithm

Buildings
The high permeability of gravel sand increases the risk of water spewing from the screw conveyor during earth pressure balance (EPB) shield tunnelling.
Xingzhong Nong, Wenfeng Bai, Jiandang Chen, Lihui Zhang   +3 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source