Results 41 to 50 of about 100,213 (248)
FEBS Letters, EarlyView.We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source
On Second-Order Necessary Conditions for Broken Extremals [PDF]
Journal of Optimization Theory and Applications, 2014 The author gives simple proofs for second-order necessary conditions for extended weak minima for extremals with discontinuous controls in optimal control problems with initial-final state equality, inequality constraints, and running mixed state control equality constraints given by smooth functions.
openaire +2 more sources
FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Frontiers in Energy Research, 2023 In order to break through the existing battery technology of electric vehicles, this paper proposes to use heat pump air conditioning instead of the original PTC heating system potential.
Zehua Miao
doaj +1 more source
CONDITIONED REINFORCEMENT AND DISCRIMINATION IN SECOND‐ORDER SCHEDULES [PDF]
Journal of the Experimental Analysis of Behavior, 1978 Pigeons were exposed to multiple second‐order schedules in which responding on the “main key” was reinforced according to either a variable‐interval or fixed‐interval schedule by production of a brief stimulus on the “brief‐stimulus key”. A response was required to the brief stimulus during its fourth (final) presentation to produce food; responses to ...
J E, Rose, E, Fantino
openaire +2 more sources
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
BMC Neuroscience, 2012 Background Classical conditioning has been suggested to play an important role in the development, maintenance, and relapse of tobacco smoking. Several studies have shown that initially neutral stimuli that are directly paired with smoking are able to ...
Littel Marianne, Franken Ingmar HA
doaj +1 more source