Results 41 to 50 of about 10,869 (265)
Second-Order Subdifferential Optimality Conditions in Nonsmooth Optimization
SIAM Journal on OptimizationThe paper is devoted to deriving novel second-order necessary and sufficient optimality conditions for local minimizers in rather general classes of nonsmooth unconstrained and constrained optimization problems in finite-dimensional spaces. The established conditions are expressed in terms of second-order subdifferentials of lower semicontinuous ...
Khanh, P. D. +3 more
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Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
AxiomsIn this paper, we study the optimality conditions and perform a stability analysis for the second-order cone constrained variational inequalities (SOCCVI) problem.
Li Wang +4 more
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On a Class of Second-Order PDE&PDI Constrained Robust Modified Optimization Problems
Mathematics, 2021 In this paper, by using scalar multiple integral cost functionals and the notion of convexity associated with a multiple integral functional driven by an uncertain multi-time controlled second-order Lagrangian, we develop a new mathematical framework on ...
Savin Treanţă
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FEBS Letters, EarlyView.We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Optimal Control through Leadership of the Cucker and Smale Flocking Model with Time Delays
Complexity, 2021 The Cucker and Smale model is a well-known flocking model that describes the emergence of flocks based on alignment. The first part focuses on investigating this model, including the effect of time delay and the presence of a leader.
Adsadang Himakalasa, Suttida Wongkaew
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Second-Order KKT Optimality Conditions for MultiObjective Optimal Control Problems [PDF]
SIAM Journal on Control and Optimization, 2018 34 ...
Kien, Bui Trong +2 more
openaire +3 more sources
Molecular Oncology, EarlyView.A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath +13 more
wiley +1 more source
A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression
Molecular Oncology, EarlyView.Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak +8 more
wiley +1 more source