Results 51 to 60 of about 260,772 (213)
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Molecular Oncology, EarlyView.Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen +14 more
wiley +1 more source
LanguagesPrevious research has shown that readers experience stronger immersion while reading first-person narratives than third-person narratives, but whether this difference in processing is time-sensitive remains unclear.
Patricia Sánchez Carrasco +2 more
doaj +1 more source
Syarat Kesehatan Fisik Bagi Calon Presiden dalam Perspektif Politik Islam dan Politik Indonesia
Ahkam: Jurnal Ilmu Syariah, 2017 This article specifically discusses the important issues on physical health requirements for presidential candidates in Islamic and Indonesian perspectives.
Mujar Ibnu Syarif
doaj +1 more source
Molecular Oncology, EarlyView.Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski +12 more
wiley +1 more source
Second Persons and the Constitution of the First Person
Humana.Mente: Journal of Philosophical Studies, 2019 Philosophers and Cognitive Scientists have become accustomed to distinguishing the first person perspective from the third person perspective on reality or experience.
Jay L. Garfield
doaj
AKAR BANALITAS INTELEKTUAL (SUATU KAJIAN FILSAFAT ILMU)
Jurnal Filsafat, 2013 This research starts from the problems of education in Indonesia in which Heru Nugroho call them “intellectual banality”. The intellectual banality is a situation which is characterized by unconscious superficiality of thought, and degradation of ...
Anastasia Jessica Adinda S.
doaj +1 more source
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
SAGE OpenTelepractice (TP) refers to the use of telecommunication devices for remote psychological and medical assessment and treatment. To date, no study involving healthy adults has combined TP with Theory of Mind (ToM), that is, the ability to understand and ...
Traetta Ilaria +2 more
doaj +1 more source
Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae
FEBS Open Bio, EarlyView.Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj +3 more
wiley +1 more source