Results 71 to 80 of about 2,365,205 (295)
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Frontiers in PsychologyCurrent psychopathology models have evolved toward dimensional models, in which symptoms and diseases are at the extremes of dimensions. Despite these new dimensional proposals, classifications and third-person approach have shown limitations.
Lisa Ouss
doaj +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Sickness in Storytelling: The Effects of Chronic Illness on Memoir and the Author [PDF]
, 2019 The thesis will be in two parts, research and creative. The first part will be a research-based paper exploring how the creation and content of memoir is influenced by authors with chronic illness, and the difficulties and unique perspective these ...
Jackson, Sarah
core +1 more source
A second-person model to anomalous social cognition [PDF]
, 2018 Reports of patients with schizophrenia show a fragmented and anomalous subjective experience. This pathological subjective experience, we suggest, can be related to the fact that disembodiment inhibits the possibility of intersubjective experience, and ...
Hipólito, Inês, Martins, Jorge
core +2 more sources
FEBS Letters, EarlyView.Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas +3 more
wiley +1 more source
Analiza i EgzystencjaThe aim of this article is to present the microphenomenological interview method as a second-person method in the study of experience. Researchers in the field of cognitive science are beginning to realize that third-person methods of studying experience
Paweł Gwiaździński, Magdalena Reuter
doaj +1 more source
Language Literacy: Journal of Linguistics, Literature, and Language Teaching, 2019 Narrations become very important such that, we tend to try to make others want to fit into them to identify with us, which is why narrative is often used in the recount of events, the past, geared to justify the systems of domination and control evident ...
Jihad Jaafar Waham, Wan Mazlini Othoman
doaj +1 more source
Integrating Ethics with Psychiatry. The case of Antoni Kępiński [PDF]
, 2016 This paper argues that in the case of mental illnesses whose somatic bases are not known or do not exist, a promising route to understand mental illness is to see it as the lack of a patient’s engagement with some moral values that are necessary for a ...
Łuków, Paweł
core +2 more sources
FEBS Letters, EarlyView.Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley +1 more source