Results 81 to 90 of about 2,365,205 (295)
AAA+ protein unfoldases—the Moirai of the proteome
FEBS Letters, EarlyView.AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley +1 more source
Eliciting Behavior From Interactive Narratives: Isolating the Role of Agency in Connecting With and Modeling Characters [PDF]
, 2015 A key component differentiating interactive storytelling from non-interactive media is agency, or control over character choices. A series of experiments show that providing agency over a character increased the user-character connection, which then ...
Barnard, Lisa +2 more
core +3 more sources
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
The fish in the creek is sentient, even if I can’t speak with it
Trans/Form/Ação: In this paper I argue that Velmens’ reflexive model of perceptual consciousness is useful for understanding the first-person perspective and sentience in animals.
Michael L. Woodruff
doaj +1 more source
Resoundings of the flesh: Caring for others by way of “second person” perspectivity
International Journal of Qualitative Studies on Health and Well-being, 2012 In bringing ourselves to the encounter with the experience of others, we bring our bodies with us-and, in doing so, we are able to resonate not only intellectually but also empathically with the other's experiences and expressions (which are given to us both verbally and nonverbally).
openaire +3 more sources
Perspective Taking Through Simulation
, 2005 Robots that operate among humans need to be able to attribute mental states in order to facilitate learning through imitation and collaboration. The success of the simulation theory approach for attributing mental states to another person relies on the ...
Demiris,Y.K.,, Johnson,M.R.,
core
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Syarat Kesehatan Fisik Bagi Calon Presiden dalam Perspektif Politik Islam dan Politik Indonesia
Ahkam: Jurnal Ilmu Syariah, 2017 This article specifically discusses the important issues on physical health requirements for presidential candidates in Islamic and Indonesian perspectives.
Mujar Ibnu Syarif
doaj +1 more source
Does Intraindividual Variability of Personality States Improve Perspective Taking? An Ecological Approach Integrating Personality and Social Cognition [PDF]
, 2018 Research integrating cognitive abilities and personality has focused on the role of personality traits. We propose a theory on the role of intraindividual variability of personality states (hereafter state variability) on perspective taking, in ...
Asselmann, Eva +4 more
core +2 more sources