Results 61 to 70 of about 2,365,205 (295)

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Non-fatal disease burden for subtypes of depressive disorder: population-based epidemiological study [PDF]

, 2016
Background: Major depression is the leading cause of non-fatal disease burden. Because major depression is not a homogeneous condition, this study estimated the non-fatal disease burden for mild, moderate and severe depression in both single episode and ...
AC Leon, AJ Ferrari, Anneke van Schaik, BM Craig, C Murray, CBS Statistics Netherlands, CD Mathers, CJ Murray, Claudi L.H. Bockting, E Bromet, Filip Smit, G Andrews, G Andrews, Gemma D. Kok, Harm W.J. van Marwijk, Henriette E. van der Horst, HU Wittchen, J Alonso, J Brazier, J Neumann Von, J Spijker, JA Salomon, JE Ware, JE Ware Jr, JM Haro, Karolien E.M. Biesheuvel-Leliefeld, M Baker, M Have Ten, M Knight, M Locadia, Margreet ten Have, ME Kruijshaar, National Center for Vital and Health Statistics, P Cuijpers, P Dolan, R Graaf de, R Graaf de, R Graaf de, RC Kessler, RC Kessler, RC Kessler, Ron de Graaf, RV Bijl, SI Saarni, T Vos, T Vos, WE Broadhead, World Health Organization, X Badia   +48 more
core   +4 more sources

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

First-Person Video Modeling as a Way of Teaching Imitation of Children with Autism [PDF]

Клиническая и специальная психология, 2018
The article discusses the problem of the basic factors of ASD: the deficit in the Theory of Mind (ToM) as the ability to represent Self-Other relationship, or violation of the ability to simulate, as the ability to transfer the perspective of Other’s ...
Novgorodtseva A., Yakovleva N.
doaj   +1 more source

Cancer related PTSD symptoms in patients of all ages and their relatives, and general risk factors [PDF]

, 2017
Since the DSM-IV, a life threatening disease is considered as a potential source of PTSD. One of the core elements of the diagnosis is experiencing a traumatic event or being a witness of a close person experiencing it.
Paleczna, Monika
core   +3 more sources

On the path of time: Temporal motion in typological perspective [PDF]

, 2020
The Moving Ego and Moving Time metaphors have provided a fertile testing ground for the psychological reality of space–time metaphors. Despite this, little research has targeted the linguistic patterns used in these two mappings.
Duffy, Sarah, Feist, Michele
core   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Harboring alien lifeworlds: The second-person in thought insertion

Cuadernos de Filosofía Latinoamericana
In phenomenology, the delusion of thought insertion is described and explained in different ways. There is a common idea that the delusion depends either on a lack of sense of agency or on a confusion between self and others. I propose that the delusion
María Clara Garavito
doaj   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source