Results 51 to 60 of about 10,174,341 (277)

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

Does Second Language Instruction Make a Difference? A Review of Research [PDF]

, 1982
Does second language instruction promote second language acquisition? Some studies conclude that instruction does not help (or even that it is counter-productive); others find it beneficial. The picture becomes clearer if two distinctions are made. First,
Long, Michael H.
core   +1 more source

Second language learners’ achievement in literature through problem-based learning method

Journal of the Scholarship of Teaching and Learning, 2009
Teaching literature to L2 learners demands methodological training and innovative strategies to bring effectiveness in learning. Problem based instructional strategy is being widely used to determine its impact on learner’s achievement, retention ...
Muhammad Athar Hussain, Muhammad Nafees, Nabi Bux Jumani   +2 more
doaj  

Prospecting the protein design landscape

FEBS Letters, EarlyView.
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona, Katharina T. Stonig, Jens Meiler, Clara T. Schoeder, Monica L. Fernández‐Quintero   +4 more
wiley   +1 more source

Corrective recasts' and other-correction of language form in interaction among native and non-native speakers of English: the application of conversation analysis to second language acquisition [PDF]

, 2003
This study investigates 'corrective recasts' and other-correction of language form during interaction among native and non-native speakers meeting at a conversation club at an English language school.
Hauser, Eric K.
core   +1 more source

Pengaruh Metode Pembelajaran dan Tipe Kepribadian Terhadap Hasil Belajar Bahasa Arab (Studi Eksperimen Pada MAN 1 Semarang)

Nadwa, 2016
This study aims to analyze: (1) The difference of students‟ achievement between students studying at cooperative learning class and those studying at conventional learning class; (2) The difference of students‟ achievement between the introvers and the ...
Nur Maziyah Ulya
doaj   +1 more source

Do learners’ beliefs matter? Self-efficacy and second language achievement among Iranian second language learners [PDF]

, 2021
Through interviews with eight Iranian participants, this Major Research Paper explores second language adult learners’ beliefs about their abilities in performing English language tasks. Primary research questions include: (i) Do learners’ self-efficacy or beliefs about their competency in acquiring a second language affect their language learning ...
openaire   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Effects of Task Complexity on Second-Language Production [PDF]

, 2002
In task-based syllabus design, task sequencing in terms of task complexity, defined by the cognitive demands imposed by the task structure itself, has been a valid candidate for an objective and prospective approach to task-based syllabus design.
Kong, DongKwan
core   +1 more source