Results 41 to 50 of about 36,288 (236)
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Group Work, Interlanguage Talk and Second Language Acquisition [PDF]
, 1985 The use of group work in classroom second language learning has long been supported by sound pedagogical arguments. Recently, however, a psycholinguistic rationale for group work has emerged from second language acquisition research on nonnative speaker ...
Long, Michael, Porter, Patricia
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The Acquisition of Sociolinguistic Native Speech Norms: Effects of a Year Abroad on Second Language Learners of French [PDF]
, 2023 One of the perennial debates in language teaching is the one about the benefits, or otherwise, of time spent abroad -- learning the language while immersed in the target speech community. After all, as Gardner (1979) says, in acquiring a second language "
Regan, Vera
core +2 more sources
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Advanced second language segmental and suprasegmental acquisition [PDF]
, 2018 This chapter presents an overview on three fundamental questions in regard to advanced second language (L2) segmental and suprasegmental acquisition. They include (a) how L2 learners improve and attain advanced L2 speech abilities through extensive and ...
Saito, Kazuya, Kazuya Saito
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Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Journal of Education, Health and Sport, 2023 International Chinese language education has long been incorporated into the theoretical framework of Second Language Acquisition (SLA), while Chinese is being learned as a third language in most overseas countries.
Ying Tang
doaj +1 more source
Usage-based and emergentist approaches to language acquisition [PDF]
, 2009 It was long considered to be impossible to learn grammar based on linguistic experience alone. In the past decade, however, advances in usage-based linguistic theory, computational linguistics, and developmental psychology changed the view on this matter.
Behrens, Heike, Heike Behrens
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Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
Bilingual first language acquisition: the nature of the weak language and the role of the input [PDF]
, 2011 This thesis investigates the development of the weak language in early bilingual language acquisition and its results are based on longitudinal and experimental data from 4 Italian-English bilingual children and their parents.
La Morgia, Francesca
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