Results 121 to 130 of about 13,925,210 (307)

Second Line Chemotherapy for Pancreatic Cancer

open access: yesThe Korean Journal of Gastroenterology, 2011
Pancreatic cancer is a very lethal cancer. It is the 5th most common cause for cancer related mortality in Korea. Most of patients have unresectable pancreatic cancer, and systemic chemotherapy remains the only treatment option for them. Gemcitabine has been adopted as the standard first-line agent for advanced pancreatic cancer, but the progression ...
openaire   +2 more sources

DNA ligase LigE increases bacterial transformation with damaged extracellular DNA

open access: yesFEBS Letters, EarlyView.
The DNA ligase LigE from the naturally competent Gram‐negative bacterium Neisseria gonorrhoaea increases transformation with cut extracellular DNA. This process is ATP‐dependent and relies on the catalytic activity of LigE; it also requires that LigE contains an intact periplasmic localisation sequence, indicating that ligE functions in the periplasm ...
Jolyn Pan   +4 more
wiley   +1 more source

Short-Term Effectiveness of Ustekinumab in Crohn’s Disease: Results from a Real-World Retrospective Multicenter Study in China

open access: yesInternational Journal of General Medicine
Xiuli Zhu,1,* Xiaoli Fang,2,* Qiaomin Wang,1 Ming Li,2 Kaiguang Zhang,1 Li Xie,1 Xiaoping Niu,3,4 Song Wang5 1Department of Gastroenterology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and ...
Zhu X   +7 more
doaj  

Peran Second Line dalam Musnad Ahmad bin Hanbal

open access: yesMutawatir: Jurnal Keilmuan Tafsir Hadith, 2015
Ibn H{anbal was a great mujaddid Islam with the final work hadith titled al-Musnad. Musnad is a hadith which contains a range of devices beyond the author himself, namely: (1) the teacher as transmitter of the tradition, (2) management through the ...
Shokhi Huda
doaj  

A novel on-line approach for evaluating transmission errors in harmonic drives

open access: yesAdvances in Mechanical Engineering
The health condition monitoring of harmonic drives plays an important role in ensuring the rotational motion accuracy of robot or manipulator joints. Capitalizing on the periodic and repetitive nature of manipulator tasks, a novel on-line data-driven ...
Songhui Zhang   +5 more
doaj   +1 more source

Dealer on-line registration system

open access: yes, 1999
Rev. 10/99; Title from cover.; "Dealer On-Line Procedure Manual"--Intro.; Accompanied by 1 sheet of automobile registration cards and 1 application for duplicate certificate of title, with cover sheet.; Harvested from the web on 11/13 ...
Connecticut. Dept. of Motor Vehicles. Dealers and Repairers Division.
core  

Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy

open access: yesFEBS Letters, EarlyView.
The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley   +1 more source

Comparison of gefitinib as first- and second-line therapy for advanced lung adenocarcinoma patients with positive exon 21 or 19 del epidermal growth factor receptor mutation

open access: yes, 2017
Nishant Patel,1 Pingping Wu,2 Haijun Zhang1 1Department of Oncology, Zhongda Hospital, Medical School, Southeast University, 2Department of Medical Oncology, Jiangsu Cancer Hospital, Nanjing, People’s Republic of China Objectives: Gefitinib, a ...
Patel N, Wu P, Zhang H
core  

Survival endpoints in second line in patients treated in first line with sunitinib.

open access: yes, 2014
Survival endpoints in second line in patients treated in first line with sunitinib.
Mauricio Burotto (559371)   +5 more
core   +1 more source

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

open access: yesFEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana   +3 more
wiley   +1 more source

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