Results 231 to 240 of about 13,925,210 (307)

A phase II study to evaluate the efficacy of commercially available molecularly matched targeted therapies in the second-line setting. [PDF]

Oncologist
Jones S, Falchook G, Graff S, Arrowsmith E, Kilari D, Gersten TA, Hussein M, Percent I, Burris HA.   +8 more
europepmc   +1 more source

Dual native G‐quadruplex folding is associated with chromatin looping at the MYC locus

FEBS Open Bio, EarlyView.
BG4‐detectable G‐quadruplex (G4) in HaCaT and NHEK keratinocytes identified folded and unfolded G4s enriched at promoters/TSSs and active enhancers, whereas unfolded G4s also overlapped weak/poised enhancers. At MYC–PVT1, 3C‐qPCR detected enhancer–promoter looping only when G4s were simultaneously folded at both regulatory elements under native ...
Dieila Giomo de Lima, Gustavo Narvaes Guimarães, Emilyane de Oliveira Santana Amaral, Bianca Caroline Figueiredo Bianco, Manuel Jara‐Espejo, Sérgio Roberto Peres Line, Ana Paula de Souza, Aline Cristiane Planello   +7 more
wiley   +1 more source

Comparative Evaluation of the Effectiveness of Nivolumab Versus Axitinib in the Second-Line Treatment of Patients with Metastatic Renal Cell Carcinoma: A Two-Center Experience. [PDF]

J Clin Med
Buğday İ, Onur İD, İnanç M, Özkan M, Bozkurt O.   +4 more
europepmc   +1 more source

Avidin is evolutionarily conserved in fish but dispensable for development and resistance against Streptococcus agalactiae in zebrafish

FEBS Open Bio, EarlyView.
The presence of biotin‐binding avidin proteins in fish and their biological significance are poorly characterized. We cataloged fish avidins and demonstrate that they are widely present and evolutionarily conserved. We created avd knockout zebrafish and show that zebavidin is dispensable for development and that resistance of avd knockout embryos in ...
Anni K. Saralahti, Markus J. T. Ojanen, Mataleena Parikka, Otto Kauko, Mika Rämet, Vesa P. Hytönen   +5 more
wiley   +1 more source

Outcomes of second-line axicabtagene ciloleucel for large B-cell lymphoma in the UK. [PDF]

Hemasphere
Kuhnl A, Kirkwood AA, Northend M, Besley C, Uttenthal B, Norman J, Hiew H, Seymour F, Maybury B, Osborne W, Sillito F, Abdulgawad A, Jones C, McCarthy P, Panopoulou A, Gribben JG, Bataillard E, Martinez-Calle N, Gajendran L, O'Reilly M, Kumar E, Wilson RP, Kasivisvanathan S, Fadlelmula N, Pryce A, Awofisayo O, Maraj A, Townsend W, Cwynarski K, Paneesha S, Mathew A, Dulobdas V, El-Sharkawi D, Creasey T, Warren M, Malladi R, Owen M, Waraich M, Ediriwickrema K, Froggatt J, Delaney A, Davies AJ, Alajangi R, Collins GP, Sanderson R, Roddie C, Menne T, Chaganti S.   +47 more
europepmc   +1 more source

Using cell‐free RNA to identify B‐ and T‐cell clonality for diagnosis and monitoring of B‐ and T‐cell neoplasms

FEBS Open Bio, EarlyView.
Using peripheral blood for determining B‐cell or T‐cell clonality is more reliable when we use cell‐free RNA (cfRNA) because cells release blood significantly more RNA than DNA. Next‐generation sequencing (NGS) of cfRNA allows us to evaluate fragment cfRNA and evaluate clonality reliably without the need for prior determination of the specific dominant
Adam Albitar, Sally Agersborg, Ahmed Charifa, Pooja Phull, Noa Biran, David Vesole, Harsh Parmar, Andrew Pecora, Andrew Ip, Andre Goy, David Siegel, Maher Albitar   +11 more
wiley   +1 more source

Structural and biochemical insights into the thermostable esterase Ta0887 from Thermoplasma acidophilum

FEBS Open Bio, EarlyView.
In this study, a novel esterase from the thermoacidophilic archaeon Thermoplasma acidophilum was biochemically and structurally characterized. Our results demonstrate that Ta0887 is a highly thermostable esterase that preferentially hydrolyzes p‐nitrophenyl hexanoate and possesses an α‐helical cap domain that likely contributes to its substrate ...
Alejandro Delgado‐Rey, Miriam Livier Llamas‐García, Gabriela M. Montero‐Morán, Leticia Santos, Samuel Lara‐González   +4 more
wiley   +1 more source

Waterloo

, 2017
D. de Fazio
core   +1 more source

Consensus statement on the management of metastatic colorectal cancer beyond the second-line therapy in Saudi Arabia. [PDF]

Int J Colorectal Dis
Bazarbashi S, Alsharm A, Alshehri A, Ibnshamsah F, Tashkandi E, Alshammari K, Al-Hajeili M, Mahrous M, Alghmadi M, Aljubran A, Alkhayyat S, Elsamany S.   +11 more
europepmc   +1 more source