Results 241 to 250 of about 13,925,210 (307)

Threonine 348 regulates the subcellular localization of PTEN

FEBS Open Bio, EarlyView.
Thr348 in the C2 domain is a key contributor to PTEN subcellular localization. The PTEN350 fragment and PTENA4 accumulated in the nucleus, whereas PTENK13R,A4 predominantly localized to the plasma membrane. In contrast, substitution of Thr348 with Asp (T348D) disrupted these characteristic localization patterns, resulting in predominant cytoplasmic ...
Takashi Kato, Suzu Tanaka, Miyu Ohashi
wiley   +1 more source

EGFR-mutant NSCLC progressing on first-line osimertinib: rebiopsy in real-world and impact of second-line therapies (the "Rebiopsy on Osi" study). [PDF]

Oncologist
Gariazzo E, Colamartini F, Cantale O, Mogavero A, Vitale A, Romano L, Peroni M, Rijavec E, Banini M, Mazzoni S, Montrone M, Pasello G, Veccia A, Ogliari FR, Leo S, Cortinovis D, Delmonte A, Belluomini L, La Cava G, Meoni G, Sini C, Delcuratolo MD, Bettini A, Pagano M, Genova C, Russo A, Pelizzari G, Tondulli L, Sergi C, Roca E, Bennati C, Grisanti S, Stanzione B, Mariotti S, Vavalà T, Soto Parra H, Ortega C, Pignataro D, Lacidogna G, Pino MS, Chiari R, Calabrò L, Pozzessere D, Masini S, Gelibter A, Scotti V, Grossi F, Tiseo M, Bria E, Metro G.   +49 more
europepmc   +1 more source

A minimal cellulosome‐like system in Cellulosilyticum lentocellum

FEBS Open Bio, EarlyView.
Cellulose‐degrading bacteria typically use cellulosomes, large multi‐enzyme complexes on a scaffold protein. In Cellulosilyticum lentocellum, we characterise a far smaller arrangement, a single scaffold bound to one cellulase through a single cohesin‐dockerin interaction.
John Allan, Amias Alstrom‐Moore, Gary W Black   +2 more
wiley   +1 more source

Clinical Outcomes of Second-Line Amrubicin and Platinum-Based Doublet Chemotherapy in Patients with Extrapulmonary Neuroendocrine Carcinoma: A Multicenter Retrospective Study. [PDF]

Cancers (Basel)
Yamakita N, Okumura T, Ota S, Yoneyama S, Noguchi T, Sekino Y, Nakamura M, Shinji A, Takeuchi N, Kanda S.   +9 more
europepmc   +1 more source

Cell surface CD11c as a neutrophil aging marker molecule

FEBS Open Bio, EarlyView.
Cell surface CD11chi neutrophils were more aged and had better phagocytic function than CD11c−/lo neutrophils. Transcriptomic analysis of CD11chi neutrophils and CD11c−/lo neutrophils in pediatric population showed that the most difference was seen in infants.
Sophia Koutsogiannaki, Fahd Alhamdan, Erik Malm, Marie Bermudez, Samuel Y. Kim, Koichi Yuki   +5 more
wiley   +1 more source

Treatment patterns and safety outcomes after splenectomy or thrombopoietin receptor agonists as second-line therapy for immune thrombocytopenia: Korean claims-based study. [PDF]

Res Pract Thromb Haemost
Lim HJ, Kwak K, Kim C, Choi YS, Park Y, Kim BS, Ahn KH, Kang KW.   +7 more
europepmc   +1 more source

Long-Term Disease Control With Second-Line Nivolumab Monotherapy in Malignant Pleural Mesothelioma: A Case Report. [PDF]

Cureus
Otsuka S, Hiraoka K, Iwashiro N.
europepmc   +1 more source

Navigating second-line therapy after immunotherapy in advanced HCC☆. [PDF]

JHEP Rep
Vogel A, Saborowski A, Rimassa L, El-Khoueiry A.   +3 more
europepmc   +1 more source

Efficacy of Second-Line Lenvatinib After Atezolizumab-Bevacizumab and Durvalumab-Tremelimumab in Unresectable Hepatocellular Carcinoma: Association with Prior Immunotherapy Response. [PDF]

Cancers (Basel)
Kuzuya T, Muto H, Tachi Y, Komura G, Nakano T, Tanaka H, Nakaoka K, Funasaka K, Nagasaka M, Miyahara R, Ohno E.   +10 more
europepmc   +1 more source