Results 121 to 130 of about 4,863,215 (291)

The newfound relationship between extrachromosomal DNAs and excised signal circles

open access: yesFEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

A Critical Review on Safi Pirlooje’s Diachronic Narrative Study: On the Rhetorics of Persian Folktales and Literary Fictions [PDF]

open access: yesپژوهش‌نامۀ انتقادی متون و برنامه‌های علوم انسانی, 2018
This paper aims to look at the form and the content of a book entitled, A Diachronic Narrative Study: On the Rhetorics of Persian Folktales and Literary Fictions (Safi, 20015) in a much more critical way, taken mostly from the narratological approaches ...
Abolfazl Horri
doaj  

Deiksis Dalam Novel "Assalamualaikum Beijing" Karya Asma Nadia (Suatu Kajian Pragmatik) [PDF]

open access: yes, 2016
ABSTRAC The aims of this study is to identify, classify and analyze the types of deixis in the novel "Assalamulaikum Beijing" by Asma Nadia and explain why authors use deixis in the novel "Assalamulaikum Beijing".
TOLOGANA, W. (WALSET)
core  

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

open access: yesFEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman   +2 more
wiley   +1 more source

Can externally activated trait concepts affect person judgments after encoding?,. [PDF]

open access: yes
Current knowledge accessibility research assumes primed trait concepts to have no biasing effects beyond the encoding stage. In a series of studies, we challenge this assumption.
Lerouge, D, Smeesters, D, Warlop, Luk
core  

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

open access: yesFEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka   +11 more
wiley   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

open access: yesFEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva   +10 more
wiley   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Context-aware CNNs for person head detection

open access: yes, 2015
Person detection is a key problem for many computer vision tasks. While face detection has reached maturity, detecting people under a full variation of camera view-points, human poses, lighting conditions and occlusions is still a difficult challenge. In
Laptev, Ivan   +2 more
core   +1 more source

The answers are within me. An evaluation of a person centred counselling service for men at HMP Doncaster who have had experience of domestic violence 2005-2007 [PDF]

open access: yes, 2008
This report is the second year evaluation of the person centred counselling service for male victims and perpetrators of domestic violence at HMP Doncaster in 2006/7.
Cadet, N.   +3 more
core  

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