Results 151 to 160 of about 1,581,172 (300)

The risk of second primary cancer after nasopharyngeal cancer: a systematic review. [PDF]

Eur Arch Otorhinolaryngol, 2023
Svärd F, Alabi RO, Leivo I, Mäkitie AA, Almangush A.   +4 more
europepmc   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

Trends and age, sex, and race disparities in time to second primary cancer from 1990 to 2019. [PDF]

Cancer Med, 2023
Leung TH, El Helali A, Wang X, Ho JC, Pang H.   +4 more
europepmc   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Incidence Differences Between First Primary Cancers and Second Primary Cancers Following Skin Squamous Cell Carcinoma as Etiological Clues

Clinical Epidemiology, 2020
Guoqiao Zheng,1– 3 Kristina Sundquist,4– 6 Jan Sundquist,4– 6 Asta Försti,1,4,7,8 Akseli Hemminki,9,10 Kari Hemminki1,2,4,11 1Division of Molecular Genetic Epidemiology, German Cancer Research Center (DKFZ), Heidelberg D-69120 ...
Zheng G, Sundquist K, Sundquist J, Försti A, Hemminki A, Hemminki K   +5 more
doaj  

New 'second primary' cancers.

SADJ : journal of the South African Dental Association = tydskrif van die Suid-Afrikaanse Tandheelkundige Vereniging, 2012
The term "second primary cancers" is applied to cancers that appear to be related to pre-existing treated or untreated cancers but that are in fact entities have arisen independently and not as a result of resurgence, nor as a result of metastasis of the original primary cancer.
L, Feller, J, Lemmer
openaire   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

The Hidden Legacy: A Systematic Review and Meta-analysis of Second Primary Cancers in Retinoblastoma Survivors

Annals of Medicine and Medical Sciences
Background: Retinoblastoma (RB) is the most common intraocular malignancy of childhood, with an excellent primary cure rate. However, survivors-particularly those with hereditary forms-face a heightened lifetime risk of second primary malignancies (SPMs).
Anitha L, Abhishek Babu, Thirumagal Vaishnavi, Sruthi Swaminathan, Jamila Hameed   +4 more
doaj  

Calculation of Organ Dose Distribution (in-field and Out-of-field) in Breast Cancer Radiotherapy on RANDO Phantom Using GEANT4 Application for Tomographic Emission (Gate) Monte Carlo Simulation

Journal of Medical Signals and Sensors
Introduction: Organ dose distribution calculation in radiotherapy and knowledge about its side effects in cancer etiology is the most concern for medical physicists.
Marziyeh Behmadi, Mohammad Taghi Bahreyni Toossi, Shahrokh Nasseri, Mohammad Ehsan Ravari, Mahdi Momennezhad, Hamid Gholamhosseinian, Mohammad Mohammadi, Sibusiso Mdletshe   +7 more
doaj   +1 more source