Results 171 to 180 of about 14,604,770 (257)

Types of second primary cancer influence overall survival in cutaneous melanoma. [PDF]

BMC Cancer, 2021
Zheng G, Chattopadhyay S, Sundquist K, Sundquist J, Försti A, Hemminki A, Hemminki K.   +6 more
europepmc   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

Cancer Trends No 22. Primary Bone Cancer March

, 2014
Case numbers, tumour sites and histological types Between 1994 and 2012, 671 cases of invasive primary bone cancer were diagnosed in Ireland, an annual average of 15 female and 21 male cases (Table 1).
National Cancer Registry Ireland (NCRI)
core  

Risk of Second Primary Cancer Among Patients with Thyroid Carcinoma in Finland: A Nationwide Population-Based Study. [PDF]

Clin Epidemiol
Nikkilä R, Hirvonen E, Mäkitie A, Pitkäniemi J, Malila NK, Mäkitie RE.   +5 more
europepmc   +1 more source

Risk of thyroid as a first or second primary cancer. A population-based study in Italy, 1998-2012. [PDF]

Cancer Med, 2021
Crocetti E, Mattioli V, Buzzoni C, Franceschi S, Serraino D, Vaccarella S, Ferretti S, Busco S, Fedeli U, Varvarà M, Falcini F, Zorzi M, Carrozzi G, Mazzucco W, Gasparotti C, Iacovacci S, Toffolutti F, Cavallo R, Stracci F, Russo AG, Caldarella A, Rosso S, Musolino A, Mangone L, Casella C, Fusco M, Tagliabue G, Piras D, Tumino R, Guarda L, Dinaro YM, Piffer S, Pinna P, Mazzoleni G, Fanetti AC, Dal Maso L, for AIRTUM working group.   +36 more
europepmc   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Risk of developing a second primary cancer following a renal cell carcinoma: a systematic review and meta-analysis. [PDF]

Int Urol Nephrol
Tundealao S, Okunlola P, Titiloye T, Mayungbo B, Adegbesan A, Sajja A, Olarewaju O.   +6 more
europepmc   +1 more source

Racial and Ethnic Disparities in Survival Among People With Second Primary Cancer in the US.

JAMA Netw Open, 2023
Sung H, Nisotel L, Sedeta E, Islami F, Jemal A.   +4 more
europepmc   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

The incidence of esophageal second primary cancer in head and neck cancer patients. [PDF]

Medicine (Baltimore)
Chiou TW, Young CK, Hsu KH, Liao CT, Hu YF, Kang CJ, Huang SF.   +6 more
europepmc   +1 more source