Results 131 to 140 of about 1,581,172 (300)
Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall +14 morewiley +1 more sourceCritical research gaps and translational priorities for the successful prevention and treatment of breast cancer [PDF]
, 2013 IntroductionBreast cancer remains a significant scientific, clinical and societal challenge. This gap analysis has reviewed and critically assessed enduring issues and new challenges emerging from recent research, and proposes strategies for translating ...Gee, Julia M. W., Hulbert-Williams, Nicholas J., Anderson, Annie, Martin, S.G., Stingl, J., Key, Timothy, Hunter, MS, Walker, Rosemary, Martin, SG, Stephen Hiscox, O’Connor, Rosemary, Smalley, Matthew J., Aboagye, Eric, Williams, K.J., Christine J Watson, Annie S Anderson, Robert B Clarke, Bundred, Nigel, Tutt, Andrew N J, Jo Armes, Evans, D, Brown, N.J., Smalley, Matthew J, Clarke, R.B., Charles H. Streuli (7669838), Eric O Aboagye, Bundred, Nigel J., Groves, Ashley, Aboagye, Eric O., John M. Saxton (7244180), Watson, Christine, Watson, C.J., Montserrat Garcia-Closas (89866), Palmieri, C., Anderson, Annie S.; id_orcid, Miller, WR, Moss, SM, Evans, D., Burchell, JM, Nicola J. Brown (7596590), John F. Marshall (7957925), John M Saxton, Amanda J Harvey, Eccles, Suzanne A., Flanagan, James, Bharat Jasani, Fedor Berditchevski, Pharoah, Paul D.P., Marshall, John F., Stingl, John, Peter Schmid, Macdougall, J.E., Cliona C. Kirwan (3934682), Duffy, Stephen W, Leach, M.O., Stein, R., Eccles, Suzanne A, Hunter, Myra, Miller, William R., Howell, Anthony, Stewart G Martin, Edwards, Dylan R., Kunkler, IH, Silva, IDOSS, Miles, D.W., Paul D P Pharoah, Ian H. Kunkler (7957919), Young, L.S., Evans, DG, Galina Velikova, Goh, V., Kong, A., Jasani, Bharat, Watson, CJ, Paul DP Pharoah (7957952), Gee, JM, Streuli, CH, Berditchevski, F., Walker, R.A., Nick Hulbert-Williams, Groves, Ashley M., Moss, Sue, Sahai, E, Jones, LJ, Goh, Vicky, Leach, Martin O., Charlotte E Coles, Gary JR Cook, Berditchevski, F, Hennessy, Bryan T., Carroll, J.S., Gee, Julia MW, Jennifer E Macdougall, Armes, Jo, Garcia-Closas, M., Aboagye, Eric O, Martin, L.A., O'Connor, J.P.B., Anthony Howell (23576), Key, Timothy J, Mullan, P, Kaye J Williams, Harvie, Michelle N., Brown, NJ, Miles, David, Harvey, AJ, Rakha, Emad A, Isabel dos Santos Silva, Thompson, Alastair M., Palmieri, C, Miller, W.R., David W Miles, Velikova, Galina, Moss, S.M., Bryant, Helen E, Cox, A, Jo Armes (3480905), Reed, E., Eccles, Diana M., Marshall, JF, Cook, Gary J. R., William R Miller, Pharoah, P.D.P., Anderson, Annie S, Fedor Berditchevski (3827920), Duffy, SW, Young, Leonie, Nicola J Brown, Martin, Stewart, Hubbard, G., Saxton, John M., Dekker, Lodewijk, Brown, Nicola, Bundred, N.J., Martin, LA, Cox, Angela, Armes, J., William M. Gallagher (265756), Charlotte E. Coles (7688222), Andrew N J Tutt, Alastair M Thompson, Aboagye, EO, Simak Ali, Paul Mullan (6534653), Jones, Louise, Rosemary O'Connor (94873), Coles, Charlotte E, Evans, D. Gareth, Burchell, Joy, Jeremy P. Blaydes (7957853), Hiscox, Stephen, Deborah F. Fenlon (7957892), Robert Stein, Speirs, Valerie, Simon P. Robinson (7957958), Hulbert-Williams, N., Joy M Burchell, Claire Foster (768031), Julia MW Gee (7957898), Julia M W Gee, D Gareth Evans (7957889), Michelle Harvie (3455429), Gee, Julia M.W., Easton, Douglas F, Gescher, A.J., Jasani, B., Key, Timothy J., Bryan T Hennessy, Smalley, Matthew John, O'Connor, JP, Williams, Kaye J, Cook, Gary, Bryant, Helen E., Eccles, DM, O’Connor, JPB, Schmid, P., David W. Miles (7957937), Rakha, Emad A., Robinson, Simon P., Sue M Moss, Blaydes, J.P., John F Marshall, Jason S Carroll, Langdon, Simon P, Cook, Gary Jr, Fenlon, D.F., Macdougall, Jennifer E., Sue M. Moss (7957943), Douglas F. Easton (7957880), Suzanne A Eccles, Evans, D.G., Angela Cox (76913), Harvey, A.J., Rosemary A Walker, Howell, A., Stein, Robert, Evans, D.Gareth, Martin, Stewart G., Edwards, Dylan, David J. Mann (2820133), O'Connor, R, Jennifer E. Macdougall (7957934), Hennessy, Bryan T, Edwards, Joanne, O'Connor, James P. B., Carroll, Jason, Anderson, A.S., Gill Hubbard (3403994), Robinson, SP, Groves, Ashley M, Hulbert-Williams, N, Watson, Christine J, Amanda J. Harvey (7957904), Kirwan, Cliona C.; id_orcid, Speirs, V, Campbell, AM, Cook, Gary J., Bryant, Helen, Coles, Charlotte E., Fenlon, Deborah F., Martin, Lesley, Blaydes, Jeremy P, Martin O Leach, Erik Sahai, Ashley M. Groves (7957901), Williams, Kaye J., Langdon, Simon P., O’Connor, James P., Bryant, HE, Edwards, J, Blaydes, JP, Emad A Rakha, Morris, Joanna R., Groves, A.M., Louise J Jones, Thompson, AM, Easton, Douglas F., Dekker, LV, Jasani, B, Harvey, Amanda J., Howell, S.J., Anna M Campbell, Saxton, JM, Vicky Goh (577982), Leach, Martin O, Stephen W Duffy, Tutt, Andrew NJ, Ali, S., Blaydes, Jeremy P., Howell, Sacha J.; id_orcid, Louise J. Jones (7957916), Harvie, Michelle, Clarke, Robert B, Lesley Ann Martin, Garcia-Closas, Montserrat, Kunkler, Ian H., Angela Cox, Leach, MO, Fenlon, Deborah, dos Santos Silva, Isabel, Leonie Young (7895759), Pharoah, Paul D. P., Harvey, Amanda, Rakha, Emad, Jones, L.J., Morris, JR, Campbell, Anna, Kunkler, Ian H, Reed, Elizabeth, Douglas F Easton, Deborah F Fenlon, Berditchevski, Fedor, Coles, C.E., Gallagher, W.M., Carlo Palmieri (681317), Howell, A, Brennan, K, Rakha, EA, Rosemary A. Walker (7580297), Jeremy P Blaydes, Duffy, Stephen, Matthew J. Smalley (7957961), Sacha J Howell, Gescher, Andy, Macdougall, JE, Elizabeth Reed (3138513), Natrajan, R., O'Connor, R., Montserrat Garcia-Closas, Bundred, Nigel J, Nicola J. Curtin (351064), Holen, Ingunn, Carroll, JS, Goh, Vicky; id_orcid, Alastair M. Thompson (7957970), Bryan Hennessy (7898999), Cook, GJR, Brown, Nicola J, Reed, E, Kirwan, CC, Hunter, Myra S., Walker, Rosemary A., Robinson, S.P., Michelle Harvie, Duffy, S.W., Saxton, John, Ingunn Holen, Suzanne A Eccles (7957850), Brennan, K., Gallagher, William, Rosemary O’Connor, Isabel Dos Santos Silva (7957874), John Stingl, Andy J. Gescher (7671179), Joanna R Morris, Annie S. Anderson (6298127), Morris, Jo; id_orcid, Langdon, Simon, Rachel Natrajan (7957946), Ali, S, Hubbard, Gill, Vicky Goh, Sacha J. Howell (7957907), Smalley, M.J., Holen, I, Sahai, E., Helen E Bryant, Edwards, Dylan R, Edwards, D.R., Cliona C Kirwan, Stein, R, Simon P Robinson, Timothy J. Key (7755380), James M Flanagan, Martin, Lesley Ann, Nick Hulbert-Williams (7957910), Morris, Joanna, Brown, Nicola J., Silva, Isabel dos Santos, Nicola J Curtin, Foster, Claire, Kaye J. Williams (7957967), Paul Mullan, Nigel J. Bundred (7957859), Curtin, NJ, Gee, Julia M W, Eccles, Diana, Campbell, Anna M, Streuli, C.H., Tutt, Andrew, Fenlon, Deborah F, Clarke, Robert B., Mullan, P., Silva, IDS, Gee, J.M.W., Morris, J.R., Valerie Speirs (1679), O'Connor, James, Cook, Gary J R, O’Connor, James P.B., Campbell, A.M., Easton, DF, Watson, Christine J., Goh, V, Bryant, H.E., Eric O. Aboagye (309960), Marshall, J.F., Howell, Anthony; id_orcid, Burchell, Joy M, Tutt, AN, Easton, Douglas, Tutt, A.N.J., Jones, Louise J, Streuli, Charles H, Hiscox, S., Schmid, Peter, Joanne Edwards (589089), Gallagher, William M, Stingl, J, Dekker, L.V., Claire Foster, Robinson, Simon P, Curtin, Nicola, Gee, Julia, Tutt, ANJ, Howell, Sacha, Saxton, J.M., Foster, C., Miles, David W, Erik Sahai (829065), Thompson, A.M., Mullan, Paul, Kirwan, Cliona C, James PB O’Connor, Mann, DJ, Rakha, E.A., Pharoah, Paul DP, Helen E. Bryant (7957856), Burchell, Joy M., Natrajan, R, Harvie, M, Carlo Palmieri, Gescher, Andy J, Macdougall, Jennifer E, Hubbard, G, Hulbert-Williams, Nick, Mann, David, Clarke, Robert, Cook, Gary J.R., Anthony Howell, Dekker, Lodewijk V, Hennessy, B.T., Young, Leonie S., Joy M. Burchell (7957862), Foster, C, Key, T.J., Moss, Sue M, Williams, Kaye, Peter Schmid (81036), D Gareth Evans, Hubbard, Gill; id_orcid, Ashley M Groves, Curtin, Nicola J., Gescher, AJ, Joanna R. Morris (7957940), Clarke, RB, Streuli, Charles, Palmieri, Carlo, Martin O. Leach (454145), Mann, David J., Ingunn Holen (3637012), Marshall, John, Simon P Langdon, Bundred, NJ, Gill Hubbard, Keith Brennan (1659), Young, LS, Timothy J Key, Kong, A, dos Santos Silva, I, Eccles, SA, Marshall, John F, Miller, William, Fenlon, DF, Charles H Streuli, Langdon, SP, Pharoah, Paul, Hunter, M.S., Streuli, Charles H., Matthew J Smalley, Smalley, MJ, Kirwan, Cliona C., Christine J. Watson (7585901), Gescher, Andy J., Tutt, Andrew N. J., Kunkler, Ian, Robinson, Simon, Keith Brennan, O’Connor, R, Eccles, S.A., Cook, G.J.R., Valerie Speirs, Kong, Hee, Curtin, N.J., Dylan R. Edwards (7957886), Hiscox, S, Edwards, DR, Gary Jr Cook (7957868), Nigel J Bundred, Eccles, Diana M, James M. Flanagan (7957895), Leach, Martin, Speirs, V., James PB O'Connor (7957949), Howell, Sacha J., Joanne Edwards, Coles, Charlotte, Emad A. Rakha (7957955), Key, TJ, Carroll, Jason S, Rachel Natrajan, Stephen W. Duffy (7957877), Walker, RA, Kong, Anthony, Eccles, Suzanne, Miles, DW, Gallagher, William M., Curtin, Nicola J, Stewart G. Martin (7957931), Ali, Simak, Jones, Louise J., Bharat Jasani (4954081), Howell, Sacha J, Mann, David J, Valikova, G., Dylan R Edwards, Macdougall, Jennifer, Blaydes, Jeremy, Miles, David W., Miller, William R, Burchell, Joy M; id_orcid, Kunkler, I.H., Anderson, AS, Armes, J, Groves, AM, Diana M. Eccles (7957883), Mann, D.J., Andy J Gescher, Flanagan, James M., O'Connor, James P B, Eccles, D.M., Garcia-Closas, M, Flanagan, J.M., Kirwan, C.C., Pharoah, Paul D P, Leonie S Young, Ian H Kunkler, Anderson, Annie S., Hennessy, Bryan, dos Santos Silva, I., Deborah Fenlon, Myra S Hunter, O'Connor, JPB, Galina Velikova (3069645), Hiscox, Stephen Edward, Carroll, Jason S., David J Mann, Holen, I., Campbell, Anna M., Flanagan, JM, Aboagye, E.O., Pharoah, PD, Velikova, G, Harvey, Amanda J, Martin, Stewart G, Sahai, Erik, Martin, L, Stephen Hiscox (361114), Cook, Gary JR; id_orcid, Coles, CE, Williams, KJ, Silva, IS, Morris, Joanna R, Lodewijk V Dekker, Hennessy, BT, Thompson, Alastair M, Simak Ali (12335), Pharoah, PDP, Saxton, John M, Cook, GJ, Evans, D. G., Andrew NJ Tutt (7957964), Simon P. Langdon (7957922), Dekker, Lodewijk V., Anna M. Campbell (7957865), Moss, Sue M., Gee, JMW, Lesley A. Martin (7957928), Harvie, M., Clarke, Robert; id_orcid, O'Connor, Rosemary, Natrajan, Rachel, Cox, A., Edwards, J., Young, Leonie S, Anthony Kong, Smalley, Matthew, Diana M Eccles, William M Gallagher, Elizabeth Reed, Schmid, P, Brennan, Keith, Langdon, S.P., Duffy, Stephen W., Easton, D.F., Walker, Rosemary A, Kirwan, Cliona, Flanagan, James M, O'Connor, James Pb, Gallagher, WM, Martin, Lesley A., Anthony Kong (94738), Gee, Julia Margaret Wendy, Howell, SJ, Hunter, Myra S, Myra S. Hunter (7957913), Lodewijk V V. Dekker (7957871), William R. Miller (1372755), Robert Stein (1704328), John Stingl (444979), Jason S. Carroll (7901276), Burchell, J.M., Robert B. Clarke (7948805) +592 morecore +1 more sourceCCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets +12 morewiley +1 more sourceHeterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig +10 morewiley +1 more sourceCell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis +10 morewiley +1 more sourceAdaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis
Molecular Oncology, EarlyView.CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová +10 morewiley +1 more sourceLongitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay +15 morewiley +1 more source
