Results 151 to 160 of about 323,138 (302)

The generalized identification of truly interfacial molecules (ITIM) algorithm for nonplanar interfaces [PDF]

, 2013
We present a generalized version of the ITIM algorithm for the identification of interfacial molecules, which is able to treat arbitrarily shaped interfaces. The algorithm exploits the similarities between the concept of probe sphere used in ITIM and the
Delaunay B. N., Marcello Sega, Miguel Jorge, Pál Jedlovszky, Small D., Sofia S. Kantorovich   +5 more
core   +1 more source

Pharmacological effects of nanoencapsulation of human-based dosing of probucol on ratio of secondary to primary bile acids in gut, during induction and progression of type 1 diabetes

Artificial Cells Nanomedicine and Biotechnology, 2018
Introduction The ratio of secondary to primary bile acids changes during Type 1 Diabetes (T1D) development and these effects might be ameliorated by using cholesterol lowering drugs or hydrophilic bile acids.
A. Mooranian, Nassim Zamani, R. Takechi, Hesham S. Al-Sallami, M. Mikov, S. Goločorbin-Kon, B. Kovacevic, F. Arfuso, H. Al‐Salami   +8 more
semanticscholar   +1 more source

Colorectal Cancer Cell's Weapon: RNF32 Engages SPP1+ Macrophages to Foster Liver Metastasis, Targeted by Indole‐3‐Acetic Acid

Advanced Science, EarlyView.
Cytoplasmic RNF32 fuels CRC liver metastasis by degrading GSK3β, which stabilizes β‐catenin and activates Wnt/EMT. Moreover, RNF32 rewires the metastatic niche: it depletes CD8+/CD4+ T and NK cells while recruiting SPP1+ macrophages (which boost tumor stemness via CD44), fibroblasts, and immunosuppressive monocytes to aid colonization.
Hongyu Wang, Shipeng Dai, Yuchen Xie, Pengyu Chen, Yue Chai, Chongyu Wang, Xueying Huang, Xiao Dong, Junfeng Shi, Yongxiang Xia, Xiaofeng Qian, Weiwei Tang, Yichan Zhou   +12 more
wiley   +1 more source

Interleukin‐18 signaling promotes activation of hepatic stellate cells in mouse liver fibrosis

Hepatology, EarlyView., 2022
Interleukin‐18 signaling promotes activation of hepatic stellate cells in mouse liver fibrosis. Abstract Background and Aims Nucleotide‐binding oligomerization domain‐like receptor‐family pyrin domain‐containing 3 (NLRP3) inflammasome activation has been shown to result in liver fibrosis.
Jana Knorr, Benedikt Kaufmann, Maria Eugenia Inzaugarat, Theresa Maria Holtmann, Lukas Geisler, Jana Hundertmark, Marlene Sophia Kohlhepp, Laela M. Boosheri, Daisy R. Chilin‐Fuentes, Amanda Birmingham, Kathleen M. Fisch, Joel D. Schilling, Sven H. Loosen, Christian Trautwein, Christoph Roderburg, Münevver Demir, Frank Tacke, Hal M. Hoffman, Ariel E. Feldstein, Alexander Wree   +19 more
wiley   +1 more source

Intestinal Absorption [PDF]

, 2000
This is the edited transcript of a Witness Seminar held at the Wellcome Institute for the History of Medicine,in London, on 9 February 1999. First published by the Wellcome Trust, 2000.
Christie, DA, Tansey, EM
core  

Identification of Giardia lamblia DHHC Proteins and the Role of Protein S-palmitoylation in the Encystation Process [PDF]

, 2014
Protein S-palmitoylation, a hydrophobic post-translational modification, is performed by protein acyltransferases that have a common DHHC Cys-rich domain (DHHC proteins), and provides a regulatory switch for protein membrane association. In this work, we
A Criscuolo, A Hiltpold, A Krogh, AB Hehl, AF Roth, AF Roth, AI Magee, Andrea S. Rópolo, B Eisenhaber, BC Jennings, BJ Davids, BJ Davids, BR Martin, BT Emmer, C Aicart-Ramos, C Aurrecoechea, C Faso, C Notredame, C Salaun, Cecilia V. Vranych, CH Sun, CH Sun, CH Wang, D Lloyd, DA Mitchell, DA Mitchell, DB Keister, DJ Bartels, DS Reiner, DS Reiner, EG Politis, F Abascal, FD Gillin, G DeJesus, GE Tusnady, GE Tusnady, HD Lujan, HD Lujan, HG Elmendorf, HG Morrison, I Letunic, I Letunic, I Slavin, J Greaves, J Greaves, J Greaves, J Pei, J Ren, J Schindelin, J Schultz, J Wan, J Yee, JA Duncan, JE Smotrys, JO Ebinu, JR Beck, JT Dunphy, K Frenal, KB Nicholas, KJ Livak, L Morf, LH Su, M Anisimova, M Fukata, M Punta, M Saric, María C. Merino, María C. Touz, MC Touz, MC Touz, MC Touz, MC Touz, MD Resh, ME Linder, ME Linder, MG De Napoli, ML Jones, ML Jones, MM Corvi, MM Zhang, MR Rivero, MS Brown, N Gottig, Nahuel Zamponi, O Batistic, O Rocks, P Papanastasiou, PG Carranza, R Tsutsumi, RD Adam, RD Finn, S Guindon, S Lobo, S Sonda, S Stoven, SE Boucher, SF Chuang, SL Planey, SM Singer, SR Birkeland, Steven M. Singer, T Hoppe, T Lauwaet, TE Nash, TE Nash, TN Petersen, TS Worgall, WF Leong, Y Fukata, Y He, Y Huang, Y Ohno, Y Webb, YC Huang, YJ Pan   +114 more
core   +3 more sources

Gut Microbiota‐Non‐Coding RNA Axis in Immune Modulation and Disease: From Mechanisms to Clinical Translation

Advanced Science, EarlyView.
ABSTRACT Immune homeostasis is indispensable for preserving organismal integrity, orchestrated through complex molecular networks encompassing immune cell dynamics, microbial cues, and epigenetic regulation. Among these, the gut microbiota‐non‐coding RNA (ncRNA) axis has recently garnered substantial attention as a multifaceted modulator of host ...
Bonan Chen, Guoming Chen, Xieyuan Leng, Qianfan Li, Wenhao Wu, Wenqiu Wu, Zixuan Liu, Zilan Zhong, Xiaohong Zheng, Wei Kang, Fazheng Ren, Yigan Zhang, Juan Chen   +12 more
wiley   +1 more source

Nicotinamide riboside and pterostilbene reduces markers of hepatic inflammation in NAFLD: A double‐blind, placebo‐controlled clinical trial

Hepatology, EarlyView., 2022
NRPT 1X reduces ALT and ceramide 14:0 in 65% of subjects as compared to only 28% in the placebo group. Abstract Background and Aims The prevalence of NAFLD is increasing globally and on a path to becoming the most frequent cause of chronic liver disease. Strategies for the prevention and treatment of NAFLD are urgently needed.
Ryan W. Dellinger, Holly E. Holmes, Tina Hu‐Seliger, Rodney W. Butt, Stephen A. Harrison, Dariush Mozaffarian, Oliver Chen, Leonard Guarente   +7 more
wiley   +1 more source

Development of ListeriaBase and comparative analysis of Listeria monocytogenes [PDF]

, 2015
Background: Listeria consists of both pathogenic and non-pathogenic species. Reports of similarities between the genomic content between some pathogenic and non-pathogenic species necessitates the investigation of these species at the genomic level to ...
Ang, Mia Yang, Choo, Siew Woh, Dutta, Avirup, Heydari, Hamed, Mutha, Naresh VR, Siow, Cheuk Chuen, Tan, Mui Fern, Tan, Shi Yang, Wee, Wei Yee, Wong, Guat Jah   +9 more
core   +3 more sources

From the Gut to the Brain: Microplastic‐Associated Neurovascular Dysfunction and Implications for Stroke Risk

Advanced Science, EarlyView.
Chronic oral exposure to microplastics may disrupt gut microbiota homeostasis and intestinal barrier integrity, potentially engaging the gut–brain axis and systemic inflammatory responses. These alterations may be associated with impaired blood–brain barrier function, cerebral microvascular dysfunction, and enhanced endothelial inflammation, pro ...
Hongxing Wang, Yujiao He, Pei Zou, Xiaoyi Wang, Gang Peng, Xiangying Deng   +5 more
wiley   +1 more source