Results 261 to 270 of about 323,138 (302)

Lactobacillus gasseri LA39 promotes hepatic primary bile acid biosynthesis and intestinal secondary bile acid biotransformation

Journal of Zhejiang University-SCIENCE B, 2023
A growing body of evidence has linked the gut microbiota to liver metabolism. The manipulation of intestinal microflora has been considered as a promising avenue to promote liver health. However, the effects of Lactobacillus gasseri LA39, a potential probiotic, on liver metabolism remain unclear.
Jun Hu, Qiliang Hou, Wenyong Zheng, Tao Yang, Xianghua Yan   +4 more
openaire   +2 more sources

Nutrition and Gastrointestinal Microbiota, Microbial-Derived Secondary Bile Acids, and Cardiovascular Disease [PDF]

Current Atherosclerosis Reports, 2020
The goal is to review the connection between gut microbiota and cardiovascular disease, with specific emphasis on bile acids, and the influence of diet in modulating this relationship.Bile acids exert a much broader range of biological functions than initially recognized, including regulation of cardiovascular function through direct and indirect ...
J. Rodríguez-Morató, N. Matthan
semanticscholar   +3 more sources

Pharmacological Effects of Secondary Bile Acid Microparticles in Diabetic Murine Model

Current Diabetes Reviews, 2022
Aim: Examine bile acids effects in Type 2 diabetes. Background: In recent studies, the bile acid ursodeoxycholic acid (UDCA) has shown potent anti-inflammatory effects in obese patients while in type 2 diabetics (T2D) levels of the pro-inflammatory bile acid lithocholic acid were increased, and levels of the anti-inflammatory bile acid ...
Mooranian, Armin, Zamani, Nassim, Kovacevic, Bozica, Ionescu, Corina Mihaela, Luna, Giuseppe, Mikov, Momir, Goločorbin-Kon, Svetlana, Stojanovic, Goran, Kojic, Sanja, Al-Salami, Hani   +9 more
openaire   +2 more sources

Modulatory nano/micro effects of diabetes development on pharmacology of primary and secondary bile acids concentrations.

Current Diabetes Reviews, 2020
BACKGROUND Recent studies have suggested that hyperglycaemia influences the bile acid profile and concentrations of secondary bile acids in the gut. INTRODUCTION This study aimed to measure changes in the bile acid profile in gut, tissues, and faeces ...
A. Mooranian, Nassim Zamani, R. Takechi, Giuseppe Antonio Di Luna, M. Mikov, S. Goločorbin-Kon, B. Kovacevic, F. Arfuso, H. Al‐Salami   +8 more
semanticscholar   +1 more source

Secondary Bile Acid Derivatives Are Contributors to the Fecal Bile Acid Pool and Associated With Bile Acid–Modulating Nutrients

The Journal of Nutrition
Accumulation of hydrophobic bile acids (BAs) is linked with cancer development. However, derivatives of deoxycholic acid (DCA) and lithocholic acid (LCA) produced via bacterial metabolism may mitigate the proinflammatory and cytotoxic effects of hydrophobic BAs. The impact of diet on secondary BA derivative production has not been determined.This study
Patricia G Wolf, Caitlin Welsh, Briawna Binion, Hanchu Dai, Manoela Lima Oliveira, Alyshia Hamm, Sarah Goldberg, Pius Sarfo Buobu, Teresa Schering, Sevasti Vergis, Nicollette Kessee, Sandra L Gomez, Cemal Yazici, Mark Maienschein-Cline, Doratha A Byrd, H Rex Gaskins, Jason M. Ridlon, Ece Mutlu, Chris Greening, Lisa Tussing-Humphreys   +19 more
openaire   +2 more sources

Primary and Secondary Bile Acids Activate Hepatic Stellate Cells

The FASEB Journal, 2020
The activation and proliferation of hepatic stellate cells (HSCs) is a major etiology contributing to the development and progression of liver fibrosis, cirrhosis and hepatocarcinogenesis. In response to liver injury, such as following oxidative stress, alcohol intoxication, viral infections and obesity ...
Shari Shontelle Yarde, Xingguo Cheng
openaire   +1 more source

Hydroxylation of secondary bile acids in the perfused prairie dog liver

Lipids, 1983
AbstractTaurolithocholic acid and deoxycholic acid were perfused into isolated prairie dog livers. Taurolithocholic acid was 7α‐hydroxylated to form taurochenodeoxycholic acid, whereas deoxycholic acid was conjugated and 7α‐hydroxylated to form taurocholic acid.
B I, Cohen, A K, Singhal, J, Mongelli, M A, Rothschild, C K, McSherry, E H, Mosbach   +5 more
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Effects of secondary bile acids on the intrauterine development in rats

Teratology, 1990
AbstractThe effects of secondary bile acids (lithocholic—LCA, and deoxycholic—DCA) on the in vivo development of rat embryos and fetuses were studied. Daily intraperitoneal injections of 2 ml of 1 mM LCA and of 5 mM DCA during days 6 till 15 of pregnancy resulted in an increase of resorptions among 20 day‐old fetuses to 22.8% and 9.9%, respectively, vs.
A, Zimber, I, Zusman
openaire   +2 more sources

Ratio of primary and secondary bile acids in feces

Diseases of the Colon & Rectum, 1999
Increases in fecal bile acids may play a role in colorectal carcinogenesis. The authors tested the hypothesis that high concentrations of primary and secondary bile acids are more common in patients with colon cancer than in patients with other gastrointestinal diseases.In this retrospective study the secondary bile acid deoxycholic acid and the ...
T, Kamano, Y, Mikami, T, Kurasawa, M, Tsurumaru, M, Matsumoto, M, Kano, K, Motegi   +6 more
openaire   +2 more sources

Structural Stability and Prebiotic Properties of Resistant Starch Type 3 Increase Bile Acid Turnover and Lower Secondary Bile Acid Formation

Journal of Agricultural and Food Chemistry, 2005
Microbial metabolism is essential in maintaining a healthy mucosa in the large bowel, preferentially through butyrate specific mechanisms. This system depends on starch supply. Two structurally different resistant starches type 3 (RS3) have been investigated with respect to their resistance to digestion, fermentability, and their effects on the ...
Gerhard, Dongowski, Gisela, Jacobasch, Detlef, Schmiedl   +2 more
openaire   +2 more sources