Results 61 to 70 of about 939,140 (300)

Digital Research Skills in Secondary Science Education: A Guiding Framework and University Teachers’ Perception [PDF]

, 2023
Kim N. Blankendaal-Tran, Rfg Ralph Meulenbroeks, Wouter van Joolingen   +2 more
openalex   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Relationship between activity limitation and health-related quality of life in school-aged children with cerebral palsy: a cross-sectional study

Health and Quality of Life Outcomes, 2017
Background Information on health-related quality of life is becoming increasingly important in children with cerebral palsy. This study investigated the relationship between activity limitation and health-related quality of life in school-aged children ...
Eun-Young Park
doaj   +1 more source

Active play in ASP –a matched-pair cluster-randomized trial investigating the effectiveness of an intervention in after-school programs for supporting children’s physical activity

BMC Public Health, 2020
Background Interventions directed at after school programs (ASPs) have the potential to support physical activity (PA) in young children. Research has indicated that interventions that emphasize competence building among the ASP staff can lead to ...
Kirsti Riiser, Kåre Rønn Richardsen, Anders L. H. Haugen, Siv Lund, Knut Løndal   +4 more
doaj   +1 more source

Correlation between the Need for Cognitive Closure and Narrative Creativity in Secondary Education [PDF]

, 2021
José Luis Ortega-Martín, Tatjana Portnova, Félix Zurita Ortega, José Luis Ubago-Jiménez   +3 more
openalex   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Integration Of Open Educational Resources in Course Materials: A Content Analysis of the Teacher Education Programme in Open and Distance Education

Journal of Research, Innovation, and Strategies for Education
Open Educational Resources (OER) comprise freely accessible, openly licensed educational materials that educators and learners can adapt and share for teaching and learning.
Ann Purnima Sandamini Fernando, Nawastheen Fareed Mohamed   +1 more
doaj   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Path analysis of strength, spasticity, gross motor function, and health-related quality of life in children with spastic cerebral palsy

Health and Quality of Life Outcomes, 2018
Background Measures of health-related quality of life may predict the future status of individuals with illnesses, and could therefore be a good indicator in children with cerebral palsy (CP).
Eun-Young Park
doaj   +1 more source