Results 71 to 80 of about 10,944,705 (298)

Toward a Cosmopolitan Minded Post-Secondary Ethics Education

, 2015
Tools to think about and interact with the emergence of new levels of interconnectivity and complexity in the post-secondary ethics classroom are necessary.
Schmaus, David L
core   +1 more source

Collective screening tools for early identification of dyslexia

Frontiers in Psychology, 2015
Current response to intervention models (RTI) favor a three-tier system. In general, Tier 1 consists of evidence-based, effective reading instruction in the classroom and universal screening of all students at the beginning of the grade level to identify
Olga Valéria Campana Dos Anjos Andrade, Paulo Estêvão Andrade, Simone Aparecida Capellini   +2 more
doaj   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

A survey on digital device engagement, digital stress, and coping strategies among college students in the Philippines

International Journal of Adolescence and Youth
This study surveyed 384 Filipino college students on their digital device engagement, digital stress, and coping strategies. Findings revealed that students were heavily reliant on digital devices.
Louie Giray, Jonard Nemeño, Jasmin Braganaza, Sheila May Lucero, Rex Bacarra   +4 more
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Integrating Vietnam’s Living Heritage into STEM Education: The Case of Vietnamese Conical Hat

SEAQIS Journal of Science Education
This study presents an innovative integration of STEM education with the preservation of Vietnam’s living heritage through the traditional craft of the Vietnamese conical hat at Gia Thanh Secondary School.
Quyen Dao, Son Do Hoang, Tam Tran Thi Thanh, Thuy Ngo Ngoc   +3 more
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Current Challenges Facing the Future of Secondary Education and Transition Services for Youth with Disabilities in the United States (Discussion Paper)

, 2004
A paper promoting discussion among professionals, policymakers, employers, parents, and individuals with disabilities concerning current and future challenges facing secondary education and transition services nationally.This paper is based, in part, on ...
National Center on Secondary Education and Transition
core  

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Secondary Literacy Across the Curriculum [PDF]

, 2007
This paper discusses the challenges and possibilities attendant upon successfully implementing literacy across the curriculum initiatives – or ‘school language policies’ as they have come to be known – particularly at the secondary or high school level ...
Stephen May, Wright, Noeline, Noeline Wright, May, Stephen, Wright, N   +4 more
core   +1 more source