Results 71 to 80 of about 3,439,590 (350)

The Construction of Identity in Secondary Mathematics Education [PDF]

open access: yes, 2000
Arts, Education & Law Group, School of Education and Professional StudiesNo Full ...
Boaler, Jo   +2 more
core   +2 more sources

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

open access: yesMolecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto   +13 more
wiley   +1 more source

Integrating Vietnam’s Living Heritage into STEM Education: The Case of Vietnamese Conical Hat

open access: yesSEAQIS Journal of Science Education
This study presents an innovative integration of STEM education with the preservation of Vietnam’s living heritage through the traditional craft of the Vietnamese conical hat at Gia Thanh Secondary School.
Quyen Dao   +3 more
doaj   +1 more source

Stability of the gross motor function classification system in children with cerebral palsy for two years

open access: yesBMC Neurology, 2020
Background The prognosis of gross motor function is a major concern for therapy and intervention in children with cerebral palsy (CP). The classification system for gross motor function, the Gross Motor Function Classification System (GMFCS), is actively
Eun-Young Park
doaj   +1 more source

The flipped classroom learning model as a means for acquiring the 21st century skills [PDF]

open access: yesJournal of Contemporary Education Theory & Research, 2019
In a knowledge based economy students are expected to acquire a certain set of skills that will enable them to have a positive impact in society. The 21st century skills are considered to be the answer to their social and professional inclusion and ...
Dimitra Mitsiou
doaj   +1 more source

Looked after children : observations of teacher education students on placement in secondary students [PDF]

open access: yes, 2008
This collection of accounts is the work of students of the Professional Graduate Diploma in Education Secondary(PGDE) -a one-year teacher education programme for graduates intending to become teachers in secondary schools.
Connelly, Graham, McQueen, Trish
core  

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

open access: yesMolecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra   +10 more
wiley   +1 more source

Motivation in physical education across the primary-secondary school transition [PDF]

open access: yes, 2008
The purpose of this study was to examine the temporal patterns of approach-avoidance achievement goals, implicit theories of ability and perceived competence in physical education across the transition from primary to secondary school.
Biddle, S.J.H.,   +12 more
core   +3 more sources

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

open access: yesMolecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son   +13 more
wiley   +1 more source

An Adaptive Approach to Solutions of Fredholm Integral Equations of the Second Kind

open access: yesAbstract and Applied Analysis, 2014
As an approach to approximate solutions of Fredholm integral equations of the second kind, adaptive hp-refinement is used firstly together with Galerkin method and with Sloan iteration method which is applied to Galerkin method solution.
Nebiye Korkmaz, Zekeriya Güney
doaj   +1 more source

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