Results 101 to 110 of about 3,130,306 (355)
Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source
Flow in a model turbine stator [PDF]
In view of the complex nature of the flowfield in the hot section of gas turbine engines, the need to predict heat transfer and flow losses, the possible appearance of separation and strong secondary flows, etc., the present effort is focusing upon a ...
Briley, W. R. +2 more
core +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Thermal Fluid Flow Transport Phenomenon in Unsteady Rotating Drum during Spin-Down Process
International Journal of Rotating Machinery, 2005 Numerical analysis is performed on unsteady-state thermal fluid flow transport phenomena in a rotating drum heated at constant wall temperature during a spin-down process.
Shuichi Torii, Wen-Jei Yang
doaj +1 more source
Mean velocities and Reynolds stresses in a juncture flow [PDF]
Values of three mean velocity components and six turbulence stresses measured in a juncture flow are presented and discussed. The juncture flow is generated by a constant thickness body, having an elliptical leading edge, which is mounted perpendicular ...
Hubbartt, J., Kubendran, L., Mcmahon, H.
core +1 more source
Molecular Oncology, EarlyView.Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang +3 more
wiley +1 more source
Derivation and evaluation of an approximate analysis for three-dimensional viscous subsonic flow with large secondary velocities [PDF]
An approximate analysis is presented for calculating three-dimensional, low Mach number, laminar viscous flows in curved passages with large secondary flows and corner boundary layers.
Anderson, O. L. +2 more
core +1 more source
, 2003 The properties of mesoscale Lagrangian turbulence in the Adriatic Sea are studied from a drifter data set spanning 1990-1999, focusing on the role of inhomogeneity and nonstationarity.
A. Maurizi +39 more
core +1 more source
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source