Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
NUMERICAL SIMULATION AND THEORETICAL ANALYSIS OF THE 3D VISCOUS FLOW IN CENTRIFUGAL IMPELLERS
TASK Quarterly, 2001 This paper investigates the three-dimensional viscous flow in centrifugal impellers through theoretical analysis and numerical simulations, which is a summary of the authors’ recent work.
SHUN KANG, CHARLES HIRSCH
doaj
Water Resources ResearchIn a channel confluence, different hydrodynamic characteristics can significantly affect the flow structure. As the main and tributary flow converges at the confluence, they are constrained by the recirculation zone, resulting in streamline contraction ...
Haokun Feng +5 more
doaj +1 more source
Further development of a method for computing three-dimensional subsonic viscous flows in turbofan lobe mixers [PDF]
Procedure for computing subsonic, turbulent flow in turbofan lobe mixers was extended to allow consideration of flow fields in which a swirl component of velocity may be present.
Briley, W. R. +3 more
core +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
, 2009 We present 3D hydrodynamical simulations of a jet launched from the secondary star of a binary system inside a proto-planetary nebula. The secondary star moves around the primary in a close eccentric orbit.
Alejandro C. Raga +29 more
core +1 more source
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Optimization on Secondary Flow and Auxiliary Entrainment Inlets of an Ejector by Using Three-Dimensional Numerical Study. [PDF]
Entropy (Basel), 2022 Yan J, Jiang J, Wang Z.
europepmc +1 more source
Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source