Results 101 to 110 of about 7,891,124 (254)

A Two-Stage Coordinated Frequency Regulation Strategy for Wind Turbines Considering Secondary Frequency Drop and Rotor Speed Recovery

Energies
The capability of wind turbines (WTs) to provide frequency response is crucial for future power systems with high wind power penetration. Existing strategies primarily focus on mitigating initial and secondary frequency drop (SFD), often overlooking the ...
Yufei Han, Yibo Zhou, Kexin Li
doaj   +1 more source

The Financial Inclusion Trilemma

This page contains the data necessary to replicate the results of "The Financial Inclusion Trilemma" by Adam J. Levitin, published in the Yale Journal on Regulation (2024)
Journal on Regulation, Yale
core   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

A Distributed Consensus-Based Optimal Dispatch Control Strategy for Hybrid AC/DC Microgrids

IEEE Access
This paper proposes a consensus-based distributed control strategy for optimal power dispatch, frequency control, and DC voltage regulation in islanded hybrid AC/DC microgrids (HMGs).
Muhammad Salman, Yanjun Li, Ji Xiang
doaj   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Frequency security certification based energy shaping control for wind power participation in primary frequency regulation

Frontiers in Energy Research
As converter-interfaced wind generation replaces synchronous machines, short-term inertia and governor support decline. Variable-speed wind turbines can release rotor kinetic energy for primary frequency regulation, but subsequent rotor recovery may ...
Hua Jing, Hongbin Zhang, Xingwang Wen, Luyao Ma, Yongming Zhang   +4 more
doaj   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Distributed cooperative secondary frequency control for power system penetrated with renewable energy sources and energy storage with communication time delays

International Journal of Electrical Power & Energy Systems
The increasing penetration of renewable energy sources in power systems presents frequency stability challenges, as power electronic-connected sources like photovoltaics and batteries inherently provide limited inertia and damping for frequency ...
Runfan Zhang, Xinyi Ren, Zixuan Liu, Zhaohong Bie, Chen Chen   +4 more
doaj   +1 more source