Results 91 to 100 of about 358,984 (291)

Regulating Secondary Markets in the High Frequency Age: A Principled and Coordinated Approach

Michigan Business & Entrepreneurial Law Review, 2016
Technological developments in securities markets, most notably high frequency trading, have fundamentally changed the structure and nature of trading over the past 50 years. Policymakers both domestically and abroad now face many new challenges impacting the secondary market’s effectiveness as a generator of economic growth and stability.
openaire   +2 more sources

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Revenue assessment of damage aware wind farm control for secondary frequency regulation provision [PDF]

In this paper, a case study of a wind power plant participating in the balancing market is presented and any potential revenue benefits are estimated. To make a representative performance assessment, an existing case for the frequency regulation market ...
Chapaloglou, Spyridon, Cali, Umit, Dupont, Kristian Astad   +2 more
core   +1 more source

A Coordinated Wind-Storage Primary Frequency Regulation Strategy Accounting for Wind-Turbine Rotor Kinetic Energy Recovery

Energies
To improve the dynamic response and steady-state frequency quality of a wind–storage coordinated system during primary frequency regulation, and to address the secondary frequency dip caused by rotor kinetic energy recovery when a doubly fed induction ...
Xuenan Zhao, Hao Hu, Guozheng Shang, Pengyu Zhao, Wenjing Dong, Zongnan Liu, Hongzhi Zhang, Yu Song   +7 more
doaj   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Robust Secondary Controller for Enhanced Frequency Regulation of Hybrid Integrated Power System

World Electric Vehicle Journal
This present article examines the frequency control of a dual-area interconnected hybrid power system that integrates conventional as well as non-conventional sources with additional support from electric vehicles. The complicated, non-linear behavior of
Zahid Farooq, Shameem Ahmad Lone, Farhana Fayaz, Masood Ibni Nazir, Asadur Rahman, Saleh Alyahya   +5 more
doaj   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Analysis of Primary and Secondary Frequency Control Challenges in African Transmission System [PDF]

This study analyzed the frequency control challenges within the West Africa Power Pool Interconnected Transmission System (WAPPITS) as it plans to incorporate variable renewable energy (VRE) resources, such as wind and solar energy.
Daniel J. Zimmerle, Julius Abayateye
core   +1 more source