Results 91 to 100 of about 37,344 (282)

Disruption of FGF5 in Cashmere Goats Using CRISPR/Cas9 Results in More Secondary Hair Follicles and Longer Fibers

PLOS ONE, 2016
Precision genetic engineering accelerates the genetic improvement of livestock for agriculture and biomedicine. We have recently reported our success in producing gene-modified goats using the CRISPR/Cas9 system through microinjection of Cas9 mRNA and sgRNAs targeting the MSTN and FGF5 genes in goat embryos.
Xiaolong Wang, Bei Cai, Jiankui Zhou, Haijing Zhu, Yiyuan Niu, Baohua Ma, Honghao Yu, Anmin Lei, Hailong Yan, Qiaoyan Shen, Lei Shi, Xiaoe Zhao, Jinlian Hua, Xingxu Huang, Lei Qu, Yulin Chen   +15 more
openaire   +4 more sources

Tumor‐Induced Splenic Remodeling: Mechanisms of Systemic Immunosuppression and Emerging Therapeutic Opportunities

Advanced Science, EarlyView.
ABSTRACT Despite the transformative impact of cancer immunotherapies such as immune checkpoint blockade, durable clinical responses remain limited. Increasing evidence indicates that antitumor immunity is governed not only by the tumor microenvironment, but also by systemic immune regulation mediated by peripheral immune organs. Among these, the spleen
Yuehua Liu, Xiaoqian Nie, Xiaofei Gao
wiley   +1 more source

Genetically induced cell death in bulge stem cells reveals their redundancy for hair and epidermal regeneration. [PDF]

, 2014
Adult mammalian epidermis contains multiple stem cell populations in which quiescent and more proliferative stem and progenitor populations coexist. However, the precise interrelation of these populations in homeostasis remains unclear.
Driskell, Iwona, Frye, Michaela, Humphreys, Peter, Oeztuerk-Winder, Feride   +3 more
core   +2 more sources

Selenium‐Based Nanoplatforms: An Emerging Theranostic Paradigm for Gynecological Cancers

Advanced Science, EarlyView.
This reivew summarizes Selenium as a multifunctional anticancer regulator in gynecological cancers. It reduces tumor risk, enhances therapeutic efficacy, and reduces treatment toxicity. Selenium also overcomes chemoraditherapy resistance, improving overall treatment outcomes. ABSTRACT Gynecological cancers present significant therapeutic challenges due
Hejing Liu, Yujia Zhou, Zihan Zhang, Rong Ma, Luyi Ruan, Liqing Miao, Boxin Zhang, Huihui Ji, Tianfeng Chen, Xueqiong Zhu   +9 more
wiley   +1 more source

Effect of the FA2H Gene on cashmere fineness of Jiangnan cashmere goats based on transcriptome sequencing

BMC Genomics, 2022
Background Cashmere goats are a heterogeneous hairy mammal. The fineness of cashmere can affect its economic value. Therefore, in this study, we used transcriptome sequencing techniques to analyze the gene expression profiles of the skin tissues of ...
Cuiling Wu, Jianying Li, Xinming Xu, Qi Xu, Chongkai Qin, Guifen Liu, Chen Wei, Guoping Zhang, Kechuan Tian, Xuefeng Fu   +9 more
doaj   +1 more source

Neural Potential of a Stem Cell Population in the Hair Follicle [PDF]

, 2007
The bulge region of the hair follicle serves as a repository for epithelial stem cells that can regenerate the follicle in each hair growth cycle and contribute to epidermis regeneration upon injury.
Enikolopov, G. N., Fedtsova, N., Gleiberman, A., Keyes, W. M., Maletic-Savatic, M., Manganas, L. N., Mignone, J. L., Mills, A. A., Roig-Lopez, J. L., Schones, D. E., Zhang, M. Q.   +10 more
core   +2 more sources

Dual‐Network Protein Hydrogels Promote Rapid Hemostasis and Immune‐Regulated Scarless Tissue Regeneration

Advanced Science, EarlyView.
A dual‐network protein hydrogel substantially improves hemostasis and scar‐free healing.The adaptive network maintains intimate tissue contact while providing strong wet adhesion, tunable mechanics, and controlled degradation. Concurrent ROS scavenging and M2 polarization suppress fibrotic pathways, preventing scar formation.
Xiaomei Li, Guorui Zhang, Xinyue Wang, Zhongyu Liu, Ling Yang, Yuhan Bao, Min Wei, Yonglin Chen, Yanfei Ma, Wenbo Sheng, Bo Yu, Bin Li   +11 more
wiley   +1 more source

Nuclear envelope defects cause stem cell dysfunction in premature-aging mice [PDF]

, 2012
et al.Nuclear lamina alterations occur in physiological aging and in premature aging syndromes. Because aging is also associated with abnormal stem cell homeostasis, we hypothesize that nuclear envelope alterations could have an important impact on stem ...
Espada, Jesús, Pendás, Alberto M.
core   +2 more sources

Comparative proteomic analysis of the telogen-to-anagen transition in cashmere goat secondary hair follicles

Frontiers in Veterinary Science
Secondary hair follicles (SHFs) in cashmere goats produce high-value cashmere fibers, which cyclic regulation is critical for optimizing cashmere yield and quality. This study explores the phenotypic changes and differential protein expression profiles involved in the telogen-to-anagen transition of SHFs.
Xiaoyu Han, Guizhen Gao, Guizhen Gao, Nanxiang Sun, Bai Dai, Bai Dai, Liqing Ren, Haobing Bai, Haobing Bai, Jianing Liu, Jie Liu, Jie Liu, Hongyan Zhao, Dongjun Liu   +13 more
openaire   +3 more sources

Boosting Sensory Nerve‐to‐Bone Interactions Enhances Hedgehog Mediated Calvarial Bone Repair

Advanced Science, EarlyView.
Boosting sensory nerve activity via TrkA agonism strongly accelerates calvarial bone repair in adult mice. Furthermore, single‐cell RNA sequencing and neuron–bone interactome analyses identify these sensory neurons as a direct neural source of Hedgehog pathway ligands. Consequently, these ligands drive osteoblast differentiation of skeletal progenitors,
Zhao Li, Xin Xing, Beicheng Du, Myles Zhou, Austin Z. Chen, Mary Archer, Chunbao Rao, Manyu Zhu, Masnsen Cherief, Aaron W. James   +9 more
wiley   +1 more source