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Fostamatinib had 46% durable response, with 73% steroid reduction, in this multicentre retrospective study of refractory wAIHA/ES. Hypertension, gastrointestinal (GI) distress and neutropenia occurred in 23%. Only one patient required drug discontinuation and one patient dose reduction.
Jorge N. Ruiz Lopez +16 more
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[Secondary immunodeficiency and infection].
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Overview of secondary immunodeficiency
Allergy and Asthma ProceedingsIn contrast to inborn errors of immunity (IEI), which are inherited disorders of the immune system that predispose to infections, malignancy, atopy, and immune dysregulation, secondary immunodeficiencies and immune dysregulation states (SID) are acquired impairments in immune cell function and/or regulation, and may be transient, reversible, or ...
Katherine E, Herman, Katherine L, Tuttle
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Secondary immunodeficiency in lymphoproliferative malignancies
Hematological Oncology, 2016AbstractSecondary immunodeficiencies occur as a consequence of various diseases, including hematological malignancies, and the use of pharmacological therapies, such as immunosuppressive, anti‐inflammatory, and biological drugs. Infections are the main cause of morbidity and mortality in multiple myeloma (MM) and chronic lymphocytic leukemia (CLL ...
Friman, V +5 more
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Immunodeficiency secondary to biologics
Journal of Allergy and Clinical Immunology, 2023Roxane Labrosse, Elie Haddad
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Leukemia research : a Forum for Studies on Leukemia and Normal Hemopoiesis, 2023
Secondary immunodeficiency (SID) can occur as a result of multiple factors, including hematological malignancies, hematopoietic stem cell transplantation (HSCT), immunosuppressive treatment, biologics, and anti-inflammatory drugs.
M. Ar +7 more
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Secondary immunodeficiency (SID) can occur as a result of multiple factors, including hematological malignancies, hematopoietic stem cell transplantation (HSCT), immunosuppressive treatment, biologics, and anti-inflammatory drugs.
M. Ar +7 more
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[Primary and secondary immunodeficiencies].
Therapeutische Umschau. Revue therapeutique, 2014Primary Immunodeficiencies (PID) are rare, genetically determined diseases that cause dysfunctional immunity, clinically presenting as susceptibility to infection but also as autoimmunity due to deficient immune tolerance. More than 180 PID have been described to date.
Nathan, Cantoni, Mike, Recher
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Secondary Immunodeficiencies of Horses
Veterinary Clinics of North America: Equine Practice, 2000FPT of immunoglobulin in foals is the commonest form of acquired immunodeficiency in horses. FPT predisposes foals to bacterial infections and septicemia and easily is preventable and treatable if breeding farms and veterinarians are attentive to optimum foaling management practices.
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Immunodeficiency III: secondary immunodeficiency and AIDS
2013This chapter concentrates on the defects in secondary immunodeficiencies and its principal causes. It emphasizes that secondary immunodeficiency results from some influence external to the immune system-infection, malnutrition, etc-ranging from the slightly increased risk of infection following surgery to the severe and progressive immune failure of ...
John H.L. Playfair, Gregory J. Bancroft
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